Back to results
US 2019/0290761 A1Published application
Magnetic particle conjugates, micelles, and methods of delivering agents
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsCARLOS RINALDI, SUN HAO, BRENT S. SUMERLIN
Life of this patent
Estimating the term…
Abstract
Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
Claims37
A composition comprising:
- a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer includes an agent (Agent) bonded to the polymer through thermally degradable group Q, wherein the polymer is represented by the following:
- where the polymer has one or more Q-Agent groups.
(canceled)
A composition, comprising:
- a micelle including a plurality of magnetic particles, a plurality of amphiphilic polymers, and a plurality of agents, wherein the amphiphilic polymer has a hydrophobic region and a hydrophilic region, wherein the hydrophobic region of the amphiphilic polymer is located in a central region of the micelle and the hydrophilic region is located away from the central region and forms the micelle outer boundary, wherein a portion of magnetic particles and a portion of the agents are located in the central region of the micelle, and wherein the amphiphilic polymer contains thermally labile backbone bonds.
(canceled)
(canceled)
A composition, comprising:
- a micelle having a hydrophobic core including a plurality of particles, a plurality of polymers, and a plurality of agents, wherein the polymer contains thermally labile backbone bonds, wherein the particle is a magnetic particle or a metal particle,
- wherein the micelle is encapsulated using a hydrophobic block copolymer that has thermally labile backbone bonds, wherein polymers in the micelle are hydrophobic block copolymers that have thermally labile backbone bonds, wherein the agent is bonded to the hydrophobic block copolymers that have thermally labile backbone bonds.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.