US 2019/0290756 A1 · PHARMACEUTICAL COMPOSITIONS WITH ANTI-RANKL ANTIBODIES, CALCIUM AND VITAMIN D

Abstract

The present invention provides a method of administering a pharmaceutical composition comprising anti-RANKL antibodies, calcium and vitamin D to a patient in need thereof. The method includes either administering a pharmaceutical composition comprising the anti-RANKL antibodies at a dose of 30 to 90 mg in 1-2 ml of a solution at yearly or six-month intervals, orally administering a pharmaceutical composition comprising the calcium at a dose of 400-600 mg daily, and orally administering the vitamin D at a dose of 800-1200 IU of vitamin D daily, or subcutaneously administering the anti-RANKL antibodies at a dose of 60-180 mg in 1-3 ml of solution for at least 3 weeks, orally administering the calcium at a dose of 400-600 mg daily, and orally administering the vitamin D at a dose of 800-1200 IU daily.

Claims18

Dependent claims

1-12. (canceled)

A method of administering a pharmaceutical composition comprising anti-RANKL antibodies, calcium and vitamin D to a patient in need thereof, the method comprising either:

A) administering a pharmaceutical composition comprising the anti-RANKL antibodies at a dose of 30 to 90 mg in 1-2 ml of a solution at yearly or six-month intervals;
orally administering a pharmaceutical composition comprising the calcium at a dose of 400-600 mg daily;
and
orally administering the vitamin D at a dose of 800-1200 IU of vitamin D daily;
or
B) subcutaneously administering the anti-RANKL antibodies at a dose of 60-180 mg in 1-3 ml of solution for at least 3 weeks;
orally administering the calcium at a dose of 400-600 mg daily;
and
orally administering the vitamin D at a dose of 800-1200 IU daily.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/301,737Filed 19 May 2017

Priority

DE 10 2016 006 557.520 May 2016

Published

26 Sep 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 31/592
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
A61K 31/593
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
A61K 33/06
Medicinal preparations containing inorganic active ingredients: aluminium, calcium or magnesium; Compounds thereof , e.g. clay

Pharmaceutical compositions with anti-rankl antibodies, calcium and vitamin d

Life of this patent

Pharmaceutical compositions with anti-rankl antibodies, calcium and vitamin d

Life of this patent

Abstract

Claims18