Optimized polypeptide for a subunit vaccine against avian reovirus
AssigneeGavish-Galilee Bio Applications Ltd.
InventorsJacob PITCOVSKI, Dana GOLDENBERG
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Abstract
An isolated polypeptide comprising an amino acid sequence corresponding to the amino acid residues forming a full or partial α-helical domain, the hinge domain, the β-triple spiral domain and a full or partial globular head domain of an avian reovirus sigma C protein, and lacking the amino acid sequence that is N-terminal to said α-helical domain is provided. Furthermore, a vaccine comprising, or a viral vector expressing, at least one of the isolated polypeptides of the present invention is provided.
Claims24
1-12. (canceled)
A vaccine comprising an isolated polypeptide comprising an amino acid sequence corresponding to the amino acid residues forming a full or partial α-helical domain, the hinge domain, the β-triple spiral domain and a lull or partial globular head domain of an avian reovirus sigma C protein, and lacking the amino acid sequence that is N-terminal to said α-helical domain.
A vaccine comprising a mammalian expression vector, such as pcDNA3;
- or a viral vector, such as a recombinant Marek's disease (MD) virus;
- wherein said mammalian expression vector or viral vector comprises a control element, such as a promoter, operably linked to a nucleic acid molecule comprising a nucleic acid sequence encoding at least one isolated polypeptide comprising an amino acid sequence corresponding to the amino acid residues forming a full or partial α-helical domain, the hinge domain, the β-triple spiral domain and a full or partial globular head domain of an avian reovirus sigma C protein, and lacking the amino acid sequence that is N-terminal to said α-helical domain.
A viral vector, such as a recombinant Marek's disease (MD) virus, comprising a control element, such as a promoter, operably linked to said nucleic acid molecule comprising a nucleic acid sequence encoding at least one isolated polypeptide comprising an amino acid sequence corresponding to the amino acid residues forming a full or partial α-helical domain, the hinge domain, the β-triple spiral domain and a full or partial globular head domain of an avian reovirus sigma C protein, and lacking the amino acid sequence that is N-terminal to said α-helical domain.
(canceled)
Dependencies are inferred from the claim text.