Dna antibody constructs for use against ebola virus
AssigneesThe Trustees of the University of Pennsylvania, The Wistare Institute of Anatomy and Biology
InventorsDavid WEINER, Ami PATEL
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Abstract
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.
Claims14
A nucleic acid molecule encoding one or more synthetic antibodies, wherein the nucleic acid molecule comprises at least one selected from the group consisting of
- a) a nucleotide sequence encoding an anti-Ebola glycoprotein (GP) protein synthetic antibody;
- b) a nucleotide sequence encoding a fragment of an anti-Ebola GP synthetic antibody.
Dependencies are inferred from the claim text.