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US 2019/0290740 A1Published application
Albumin-Free Botulinum Toxin Formulations
AssigneeRevance Therapeutics, Inc.
InventorsStewart A. Thompson, Curtis L. Ruegg, Jacob M. Waugh
Life of this patent
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Abstract
This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.
Claims21
A method for stabilizing a botulinum toxin formulation, the method comprising:
- combining a botulinum toxin, a non-reducing disaccharide or a non-reducing trisaccharide, a non-ionic surfactant, and a physiologically compatible buffer to form a liquid composition;
- wherein the concentration of the non-reducing disaccharide is in the range of 10% to 40% (w/v);
- and
- wherein the concentration of the non-ionic surfactant is in the range of 0.005% to 0.5% (w/v).
1 more element
The method according to claim 19, wherein the subscript n1 is an integer of from 2 (Original) to 5;
- and the subscript n2 is independently an odd integer of from 7 to 13.
21-38. (canceled)
Dependencies are inferred from the claim text.