Reduced oxygen carriers and their use for the treatment of carboxyhemoglobinemia
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJason Joseph Rose, Qinzi Xu, Mark T. Gladwin, Jesus Tejero Bravo
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Abstract
In vitro and in vivo methods of removing carbon monoxide from hemoglobin in blood or animal tissue are described. Methods of treating carboxyhemoglobinemia (carbon monoxide poisoning) in a subject are also described. The methods include administering natural or artificial oxygen carriers that are in their reduced form. Methods of producing a reduced oxygen carrier are further described. Methods of treating cyanide poisoning or hydrogen sulfide poisoning with oxygen carriers are also described.
Claims53
A method of treating carboxyhemoglobinemia in a subject, comprising:
- selecting a subject with carboxyhemoglobinemia;
- and
- administering to the subject a therapeutically effective amount of a composition comprising a natural or an artificial oxygen carrier, wherein the oxygen carrier is in its reduced form.
A method of removing carbon monoxide from hemoglobin in blood or animal tissue, comprising contacting the blood or animal tissue with a composition comprising a natural or an artificial oxygen carrier, wherein the oxygen carrier is in its reduced form, thereby removing carbon monoxide from hemoglobin in the blood or animal tissue.
(canceled)
A method of preparing a reduced oxygen carrier, comprising:
- contacting the oxygen carrier with a first reducing agent to produce an oxygen carrier-reducing agent composition;
- and
- passing the oxygen carrier-reducing agent composition over a desalting column to form a reduced oxygen carrier composition,
- wherein the preparation of the reduced oxygen carrier is performed in an anaerobic environment.
A method of treating cyanide poisoning in a subject, comprising:
- selecting a subject with cyanide poisoning;
- and
- administering to the subject a therapeutically effective amount of a composition comprising a natural or an artificial oxygen carrier, wherein the oxygen carrier is in its oxidized form.
A method of treating hydrogen sulfide (H2S) poisoning in a subject, comprising:
- selecting a subject with H2S poisoning;
- and
- administering to the subject a therapeutically effective amount of a composition comprising a natural or an artificial oxygen carrier, wherein the oxygen carrier is in its reduced form.
Dependencies are inferred from the claim text.