Methods related to breaking t cell exhaustion
AssigneeChildren's Medical Center Corporation
InventorsFlorian WINAU, Yu HU
Life of this patent
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Abstract
Described herein are methods and compostions relating to breaking or inhibiting T cell exhaustion by increasing TMEM16F levels and/or activity. The methods and compositions can thereby further relate to treatment of viral infections or cancer, treatment of a chronic disease, vaccine administration, administering a CAR-T therapy, or increasing the number of T-bet+ T cells in a subject. In some embodiments, the methods relate to treatment of an autoimmune or inflammatory disease by inhibiting TMEM16F levels and/or activity.
Claims28
A method of treating a viral infection or cancer in a subject in need thereof, the method comprising administering an agonist of TMEM16F to the subject.
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A method of administering a vaccine to a subject in need thereof, the method comprising administering:
- the vaccine;
- and an agonist of TMEM16F to the subject.
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A method of treating an autoimmune or inflammatory disease in a subject in need thereof, the method comprising administering an inhibitor of TMEM16F to the subject.
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Dependencies are inferred from the claim text.