Micro-slits for reticulocyte maturation
AssigneeUniversity of Rochester
InventorsRichard Waugh, Julia M. Kuebel, Yingye Fang, Greg Palis
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Abstract
The present disclosure relates to devices for producing mature red blood cells and methods for using the same. The devices comprise micro-slit filters that mechanically stimulate cells in custom cell medium to impart the cells with physical characteristics that enable the cells to pass through and survive human vasculature.
Claims20
A micro-slit filter device comprising at least one micro-slit channel, each micro-slit channel comprising two openings connected by a lumen, wherein the two openings and the lumen comprises a width between about 1 and 3 μm.
A method of mechanically stimulated culturing to produce red blood cells, the method comprising the steps of passing a volume of cell-containing medium through a micro-slit filter device comprising at least one micro-slit channel, each micro-slit channel comprising two openings connected by a lumen, wherein the two openings and the lumen comprises a width between about 1 and 3 μm.
Dependencies are inferred from the claim text.