Methods and reagents for modulating macrophage phenotype
AssigneeNew York University
InventorsDafna BAR-SAGI, Jane CULLIS, Craig RAMIREZ
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Abstract
The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.
Claims26
A method of inducing a phenotypic change in a population of monocytes and/or macrophages, said method comprising:
- administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein said carrier molecule facilitates macropinocytic uptake of said agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, and wherein said administering induces a phenotypic change in the monocytes and macrophages in the population.
A method of treating a tumor in a subject comprising:
- selecting a subject having a tumor and
- administering to the selected subject an anti-tumor agent coupled to a carrier molecule that is defective in neonatal Fc receptor (FcRn) binding, wherein said administering induces a therapeutic tumor cell response in the subject.
Dependencies are inferred from the claim text.