Solid pharmaceutical tablet
AssigneeFertin Pharma A/S
InventorJESPER NEERGAARD
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Abstract
The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.
Claims22
A solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication, and the organic water-insoluble components comprise elastomer in the range of 1-15% by weight of the tablet and natural and/or synthetic resin in the range of 5-35% by weight of the tablet.
A solid pharmaceutical tablet for oral delivery, the tablet comprising an active pharmaceutical ingredient in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the active pharmaceutical ingredient within 5 minutes of mastication, and the organic water-insoluble components comprise elastomer in the range of 1-15% by weight of the tablet and natural and/or synthetic resin in the range of 5-35% by weight of the tablet.
A solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 15% by weight of the tablet and organic water-insoluble components in an amount of more than 25% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication, and the organic water-insoluble components comprise elastomer in the range of 1-15% by weight of the tablet and natural and/or synthetic resin in the range of 5-35% by weight of the tablet.
A method of releasing calcium carbonate from a solid pharmaceutical tablet, the method comprising:
- a) providing a tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet,
- b) masticating the tablet into a coherent residual containing the organic water-insoluble components,
- c) generating fluid in the oral cavity,
- d) releasing more than 80% of the calcium carbonate to the fluid in the oral cavity within 5 minutes of mastication.
Dependencies are inferred from the claim text.