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US 2019/0290658 A1Published application
Therapeutic compounds and compositions for treating social disorders and substance use disorders
AssigneeThe University of Sydney
InventorsIain Stewart MCGREGOR, Michael KASSIOU, Michael Thomas BOWEN, Callum HICKS, William JORGENSEN
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Abstract
Disclosed herein are compounds, compositions and methods for the treatment of neurological, psychiatric disorders which are characterised by a fundamental disruption of social behaviour, and substance use disorders. In particular, disclosed herein are compounds of Formula (I), or salts or prodrugs thereof. Methods of treating or preventing neurological, psychiatric disorders and substance use disorders, using compounds of Formula (I), or salts and prodrugs are also disclosed.
Claims125
A compound of Formula (I), or a salt or prodrug thereof:
- wherein:
- V is NH, CH2 or a direct bond;
- W is NH, CH2 or a direct bond;
- X is NH, CH2 or a direct bond;
- Y is NH, CH2 or a direct bond;
- Z is selected from:
- NH, O, S, S(O), SO2 or a direct bond;
- R1 is selected from H or C(O)R4;
- R2 is selected from:
- H, OH, halogen, an optionally substituted C1-5alkyl or an optionally substituted OC1-5alkyl;
- R3 is selected from:
- H, OH, halogen, an optionally substituted C1-5alkyl or an optionally substituted OC1-5alkyl;
- R4 is an optionally substituted C1-5alkyl;
- m is 0 or 1;
- n is 0 or 1;
- p is 0 or 1;
- and
- q is 0 or 1.
15 more elements
Dependencies are inferred from the claim text.