Subcutaneous delivery of poly(oxazoline) polymer conjugates
AssigneeSerina Therapeutics, Inc.
InventorsRandall MOREADITH, Michael BENTLEY, Kunsang YOON, Zhihao FANG, Rebecca WEIMER, Bekir DIZMAN, Tacey VIEGAS
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Abstract
The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
Claims20
A poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure
- wherein
- L is
- R3 is a forms a linkage with the poly(oxazoline) polymer chain;
- R4 is —CH2—C(O)—O—, —CH2(CH3)—C(O)—O—, —CH2—CH2—C(O)—O— or —CH2—CH2—CH2—C(O)—O—;
- R is an initiating group;
- R1 is a non-reactive group;
- A is rotigotine;
- a is ran which indicates a random copolymer or block which indicates a block copolymer;
- o is from 1-50;
- m is from 1-1000;
- T is a terminating group;
- and
- the conjugate provides a release profile for rotigotine that is dependent on the selection of R4.
A method for treating a disease or condition related to dopamine insufficiency in the peripheral or central nervous system by administration of rotigotine, the method comprising the steps of selecting a polyoxazoline polymer conjugate for administration and administering to the subject the poly(oxazoline) polymer conjugate, wherein a release profile of the rotigotine is selectable based on the selection of the poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure:
- wherein
- L is
- R3 is a forms a linkage with the poly(oxazoline) polymer chain;
- R4 is —CH2—C(O)—O—, —CH2(CH3)—C(O)—O—, —CH2—CH2—C(O)—O— or —CH2—CH2—CH2—C(O)—O—;
- R is an initiating group;
- R1 is a non-reactive group;
- A is rotigotine;
- a is ran which indicates a random copolymer or block which indicates a block copolymer;
- o is from 1-50;
- m is from 1-1000;
- T is a terminating group;
- and
- wherein the release profile is dependent on the selection of R4.
Dependencies are inferred from the claim text.