New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors

A compound of formula (I)

• wherein
• ring system A is selected from the group consisting of A1 and A2
• R1A is selected from the group consisting of hydrogen, halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, hydroxy-C1-4alkyl, C1-4alkoxy-C1-4alkyl, —CN and 5-6 membered heteroaryl;
• each R1B is independently selected from the group consisting of hydrogen, halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, hydroxy-C1-4alkyl, C1-4alkoxy-C1-4alkyl, —CN and 5-6 membered heteroaryl;
• or
• R1A together with R1B and the atoms they are linked to form a 5-6 membered heteroaryl;
• each R2 is independently selected from the group consisting of halogen, C1-4alkyl, C1-4haloalkyl and C1-4alkoxy;
• q has the value 0, 1 or 2;
• Y is CH or N;
• R3 is selected from the group consisting of hydrogen, halogen, C1-4alkyl and C1-4haloalkyl;
• R4 is selected from the group consisting of hydrogen and C1-4alkyl;
• R5 is selected from the group consisting of —NR5AR5B, —OR5C and R5D;
• R5A, R5B and R5C, each independently of one another, denotes hydrogen or a group, optionally substituted by one or more, identical or different Rb1 and/or Rc1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rb1 is independently selected from among —ORc1, —NRc1Rc1, halogen, —CN, —C(O)Rc1, —C(O)ORc1, —C(O)NRc1Rc1, —S(O)2Rc1, —S(O)2NRc1Rc1, —NHC(O)Rc1, —N(C1-4alkyl)C(O)Rc1 and the bivalent substituent ═O, while ═O may only be a substituent in non-aromatic ring systems;
• each Rc1 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• or
• R5A together with R4 or R5C together with R4 is C1-5alkylene and R5B is selected from among hydrogen and C1-4alkyl;
• R5D denotes a 3-10 membered nitrogen containing heterocyclyl linked via a nitrogen atom and optionally substituted by one or more, identical or different Rb2 and/or Rc2;
• each Rb2 is independently selected from among —ORc1, —NRc1Rc1, halogen, —CN, —C(O)Rc2, —C(O)ORc2, —C(O)NRc2Rc2, —S(O)2Rc2, —S(O)2NRc2Rc2, —NHC(O)Rc2, —N(C1-4alkyl)C(O)Rc2 and the bivalent substituent ═O;
• each RC2 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• or a salt thereof.