Certain chemical entities, compositions and methods

A compound of Formula I-1:

• or a pharmaceutically acceptable salt thereof, wherein
• B is alkyl or a moiety of Formula II:
• wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl, and
• q is an integer of 0, 1, or 2;
• X is absent or —(CH(R9))z—, and z is an integer of 1, 2, 3, or 4;
• Y is absent, —N(R9)—, or —N(R9)CH(R9)—;
• wherein at least one of X and Y is present;
• Wd is
• Ra′ is hydrogen, halo, or amino;
• R1 is hydrogen, —F, —Cl, —CN, —CH3, isopropyl, —CF3, —OCH3, nitro, or phosphate;
• R2 is halo, hydroxy, cyano, nitro, or phosphate;
• R3 is aryl, heteroaryl, H, —CH3, —CF3, —Cl, or —F;
• each R9 is independently hydrogen, methyl, or ethyl;
• and
• R12 is hydrogen, alkyl, alkynyl, alkenyl, halo, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, cyano, amino, carboxylic acid, alkoxycarbonyl, or amido.