Non-hormonal compositions and methods for male contraception

A method for reversible continuous non-hormonal contraception in a male subject, the method comprising administering once daily doses of a composition comprising:

• an extended release formulation of alpha-1-adrenoreceptor antagonist in an amount effective, when administered on a once daily dosing regimen, to induce a reversible condition of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject;
• and
• a pharmaceutically acceptable carrier,
• wherein the failure to administer one daily dose after an initial period of two consecutive days does not affect the continuous state of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject.

A method for birth control, the method comprising administering to a male subject once daily doses of a composition comprising:

• an extended release formulation of alpha-1-adrenoreceptor antagonist in an amount effective, when administered on a once daily dosing regimen, to induce a reversible condition of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject;
• and
• a pharmaceutically acceptable carrier,
• wherein the failure to administer one daily dose after an initial period of two consecutive days does not affect the continuous state of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject.