Methods for Reducing Recurrence of Tumors
OwnerVikas Sukhatme, Dipak Panigrahyinventors
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Abstract
Methods of reducing the risk of cancer after surgery, e.g., of cancer recurrence, by administering COX-1 selective inhibitors prior to surgery or biopsy. Alternatively or in addition, other anti-platelet agents and/or TGF-β inhibition and/or IL-6 inhibition and/or inhibitors of the PD-1/PD-L1 axis, as well as combinations thereof.
Claims25
A method of reducing the risk of cancer occurrence or recurrence in a subject undergoing a surgical procedure, the method comprising administering to the subject a therapeutically effective amount of one or more of:
- (i) one or more anti-platelet agents, preferably a COX-1 specific inhibitor and/or anti-CD41 antibody,
- (ii) a TGF-β inhibitor;
- (iii) an IL-6 inhibitor;
- and/or
- (iv) a checkpoint inhibitor, preferably a Programmed cell death protein 1 (PD-1) or programmed death ligand-1 (PD-L1) inhibitor,
- wherein the administering is performed before the surgical procedure.
A method of inducing an adaptive immune response to a cancer in a subject who has cancer, the method comprising administering to the subject a therapeutically effective amount of one or more of:
- (i) an anti-platelet agent, preferably a COX-1 specific inhibitor,
- (ii) TGF-β inhibitor;
- (iii) an IL-6 inhibitor;
- and/or
- (iv) a Programmed cell death protein 1 (PD-1) or programmed death ligand-1 (PD-L1) inhibitor,
- and subsequently performing a surgical procedure in the subject.
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A method of preparing a subject for a surgical procedure, the method comprising administering to the subject a therapeutically effective amount of one or more of:
- (i) an anti-platelet agent, preferably a COX-1 specific inhibitor,
- (ii) TGF-β inhibitor;
- (iii) an IL-6 inhibitor;
- and/or
- (iv) a Programmed cell death protein 1 (PD-1) or programmed death ligand-1 (PD-L1) inhibitor,
- and subsequently performing a surgical procedure in the subject.
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Dependencies are inferred from the claim text.