Uses of Curcumin Derivative
AssigneeMerry Life Biomedical Company, Ltd.
InventorsIh-Jen SU, Kuen-Jer TSAI, Hong-Yi CHANG
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Abstract
The invention provides a method for preventing and/or treating Alzheimer's disease in a subject in need of such treatment, comprising administrating to said subject an effective amount of a curcumin derivative, TML-6, and optionally a pharmaceutically acceptable carrier or excipient.
Claims10
A method for preventing and/or treating Alzheimer's disease in a subject in need of such treatment, comprising administrating to said subject an effective amount of TML-6, or a pharmaceutically acceptable salt, solvate, hydrate, isotopologue, or prodrug of TML-6, and optionally a pharmaceutically acceptable carrier or excipient,
A method for identifying a candidate compound which may increase apolipoprotein E expression, promote beta-amyloid clearance, inhibit amyloid precursor protein synthesis, and/or inhibit inflammation in brain regions, which comprises contacting the candidate compound with AP-2 or PPARα/RXRα binding site of ApoE promoter region and determining if the candidate compound binds to AP-2 or PPARα/RXRα binding site of ApoE promoter region, wherein binding indicates that the candidate compound may increase apolipoprotein E expression, promote beta-amyloid clearance, inhibit amyloid precursor protein synthesis, and/or inhibit inflammation in brain regions.
Dependencies are inferred from the claim text.