Titration of tapentadol
AssigneeGrüNenthal GmbH
InventorsClaudia LANGE, Ferdinand ROMBOUT
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Abstract
The use of tapentadol for the manufacture of a medicament comprising at least one administration unit A containing dose a of tapentadol and at least one administration unit B containing dose b of tapentadol, where dose a<dose b, for the treatment of pain.
Claims39
Use of tapentadol for the manufacture of a medicament comprising
- at least one administration unit A containing dose a of tapentadol and
- at least one administration unit B containing dose b of tapentadol,
- where dose a<dose b,
- for the treatment of pain.
A pharmaceutical oral dosage form containing tapentadol, which comprises a notch, that divides the dosage form into at least two portions and mechanically weakens the dosage form so that it may be manually broken at the notch along a predetermined site of fracture, which contains 40 to 260 mg of tapentadol so that, after being broken at the notch along the predetermined site of fracture, each portion contains about 20 to about 130 mg of tapentadol.
A method of treating pain in a subject in need thereof, said method comprising administering said subject
- dose a of tapentadol during a first administration interval and
- dose b of tapentadol during a second administration interval following the first administration interval,
- where dose a<dose b.
Dependencies are inferred from the claim text.