Dermal and transdermal administration of treprostinil and salts thereof
AssigneeCorsair Pharma, Inc.
InventorsXiaoming ZHANG, Cyrus K. BECKER, Meenakshi S. VENKATRAMAN
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods, compositions, devices and systems for dermal and transdermal administration of treprostinil or salts thereof, and optionally an additional therapeutic agent. Treprostinil and salts thereof can be dermally or transdermally administered to treat any medical conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Claims47
A transdermal drug-delivery system (TDS) comprising treprostinil or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or polymorph thereof, and one or more pharmaceutically acceptable excipients or carriers, wherein the TDS is formulated or configured to transdermally deliver treprostinil or a salt thereof to a subject.
The TDS of any one of the preceding claims, which is integrated with a chemical or physical enhancement technique that provides an added driving force for drug transport into or/and through the skin (e.g., iontophoresis).
The TDS of any one of the preceding claims, which is integrated with a chemical or physical enhancement technique that increases skin permeability (e.g., chemical permeation enhancer, non-cavitational or cavitational ultrasound, electroporation, thermal ablation, radio frequency, microdermabrasion, microneedles or high pressure).
The TDS of any one of the preceding claims, wherein the treprostinil is the carboxylic acid form of treprostinil.
The TDS of any one of the preceding claims, further comprising an additional therapeutic agent.
A method of transdermally delivering treprostinil or a salt thereof to a subject, comprising applying the transdermal drug-delivery system of any one of the preceding claims to the skin of the subject.
A method of treating a medical condition responsive to treatment with treprostinil, comprising transdermally administering a therapeutically effective amount of treprostinil or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or polymorph thereof to a subject in need of treatment.
Treprostinil or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or polymorph thereof for use in the treatment of a medical condition responsive to treatment with treprostinil, wherein treprostinil or a salt thereof is transdermally administered.
A composition comprising treprostinil or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or polymorph thereof for use in the treatment of a medical condition responsive to treatment with treprostinil, wherein treprostinil or a salt thereof is transdermally administered.
Use of treprostinil or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or polymorph thereof in the preparation of a medicament for the treatment of a medical condition responsive to treatment with treprostinil, wherein treprostinil or a salt thereof is transdermally administered.
Dependencies are inferred from the claim text.