Nanoparticles for Brain Targeted Drug Delivery
AssigneeUniversity of South Carolina
InventorPEISHENG XU
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Abstract
A nanoparticle suitable for delivery of an active agent across the blood-brain barrier is provided. As such, the nanoparticle can target brain tissue so that the active agent can be delivered across the blood-brain barrier to the target brain tissue. The nanoparticle includes a core that includes a core material such as a polymer or inorganic material as well as an active agent; and a shell comprising a membrane derived from a brain metastatic cancer cell, wherein the brain metastatic cancer cell facilitates transport of the nanoparticle across a blood-brain barrier. Also disclosed are methods of forming the nanoparticle and methods of using the nanoparticle.
Claims28
A nanoparticle comprising:
- a core comprising a core material and an active agent;
- and
- a shell comprising a membrane derived from a brain metastatic cancer cell, wherein the membrane facilitates transport of the nanoparticle across a blood-brain barrier.
A method of forming a nanoparticle, the method comprising:
- encapsulating a core material with an active agent to form a core of the nanoparticle;
- deriving a membrane from a brain metastatic cancer cell;
- and
- coextruding the core and the membrane derived from the brain metastatic cancer cell to form the nanoparticle, wherein the membrane derived from the brain metastatic cancer cell forms a shell around the core, wherein the membrane facilitates transport of the nanoparticle across a blood-brain barrier.
A method for delivering an active agent across a blood-brain barrier of a subject, the method comprising providing to the subject a nanoparticle comprising a core and a shell, wherein the core comprises a core material and the active agent, and wherein the shell comprises a membrane derived from a brain metastatic cancer cell.
Dependencies are inferred from the claim text.