Instant release capsule based on hot melt extruded polyvinyl alcohol
AssigneeMerck Patent GmbH
InventorsMengyao ZHENG, Anja-Nadine KNUETTEL
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Abstract
The present invention relates to an improved powdered extrudate based on polyvinyl alcohol (PVA), which can be used for pharmaceutical products, and that, due to its improved properties, can be better filled into capsules and the capsules show stable immediate drug release kinetic without problem of particle aggregation. Furthermore, this invention refers to pharmaceutical capsule composition comprising extruded polyvinyl alcohol as carrier matrix and can improve the solubility of API within immediate release kinetic. Moreover, the capsule show also benefit than tablet regarding to the material cost, because just PVA and API, no additional excipients are needed for capsule.
Claims10
Extruded polyvinyl alcohol (PVA) powder, which is milled or pelletized into powder particles with particle sizes in the range of 500 μm to 3000 μm, preferably in the range of 500 μm to 1500 μm, most preferred in the range of 500 μm to 1000 μm, with improved flowability and excellent immediate drug release kinetic.
Dependencies are inferred from the claim text.