Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
AssigneeMannKind Corporation
InventorsKeith A. Oberg, Joseph Sulner, Marshall L. Grant
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Abstract
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Types of surface properties that are altered by the disclosed methods include electrostatic properties, hydrophobic properties, and hydrogen bonding properties.
Claims20
A composition comprising microparticles, comprising a diketopiperazine and polysorbate 80.
A pharmaceutical composition for pulmonary delivery comprising microparticles of a diketopiperazine, a polysorbate 80 and an active agent.
Dependencies are inferred from the claim text.