Targeted delivery of drugs to the myometrium
AssigneeThe University of Newcastle
InventorsSusan Hua, Jonathan Paul, Roger Smith
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Abstract
Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.
Claims8
A method for targeted delivery to myometrial tissue of one or more agents capable of inhibiting or reducing contractility of said myometrial tissue, comprising exposing myometrial tissue to an effective amount of the one or more agents, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with anti-oxytocin receptor antibodies or a peptide that binds to the oxytocin receptor,
- wherein the polymeric delivery vehicles containing the agent(s) are administered to a pregnant female mammal, and
- wherein the administration is to slow down labour or prevent premature labour.
Dependencies are inferred from the claim text.