Vaginal hydrogel for delivery of therapeutics
OwnerMarina Lee Gerton, Brenda K. Manninventors
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Abstract
The composition is a hydrogel which may be used to deliver therapeutics vaginally. The hydrogel may include a glycosaminoglycan. The glycosaminoglycan may include multiple thiol groups. The composition may also include a molecule that includes at least two thiol reactive sites. The composition may include a mucoadhesive agent as well as a therapeutic agent. The composition may deliver the therapeutic at a pH that is optimal for the vaginal environment, namely between about 3.5 and 5.0.
Claims20
A composition comprising at least one glycosaminoglycan, each of the at least one glycosaminoglycan comprising a plurality of thiol groups;
- a molecule comprising at least two thiol-reactive sites,
- a mucoadhesive agent, and
- a therapeutic agent,
- wherein the composition is dried, and
- wherein the composition has a pH between about 3.2 and about 5.0 when hydrated.
A composition comprising:
- a glycosaminoglycan comprising a plurality of thiol-reactive sites,
- a molecule comprising at least two thiol groups,
- a mucoadhesive agent, and
- a therapeutic agent having a solubility in water of less than about 1.0 mg/ml,
- wherein the composition is dried, and
- wherein the composition has a pH of between about 3.2 and about 5.0 when hydrated.
A method for making a drug delivery composition comprising:
- forming a mixture comprising:
- a glycosaminoglycan comprising a plurality of thiol groups,
- a molecule comprising at least two thiol-reactive sites,
- a mucoadhesive agent,
- a therapeutic agent having a solubility in water of less than about 1.0 mg/ml, and
- a buffer having a pH between about 3.2 and about 5.0;
- allowing the glycosaminoglycan and the molecule to covalently crosslink;
- and
- allowing the mixture to dry.
Dependencies are inferred from the claim text.