Orally disintegrating tablet having inner core
AssigneeSumitomo Dainippon Pharma Co., Ltd.
InventorsMitsuhiro MATONO, Hirohisa KOBAYASHI, Yuki IKEDA, Yasushi OCHIAI
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Abstract
The present invention provides an orally disintegrating tablet with improved photostability of a medicament unstable to light. The orally disintegrating tablet has an inner core and an outer layer that covers the surface of the inner core, wherein the inner core contains the medicament unstable to light and the outer layer contains a light-absorbing substance such as Red No. 2, Red No. 3, Yellow No. 4, Yellow No. 5, Blue No. 1, Red No. 3 aluminum lake, Yellow No. 4 aluminum lake, Yellow No. 5 aluminum lake, Blue No. 1 aluminum lake, Blue No. 2 aluminum lake, red ferric oxide, yellow ferric oxide, black iron oxide, carmine, or sodium copper chlorophyllin.
Claims26
An orally disintegrating tablet comprising an inner core and an outer layer that covers a surface of the inner core, wherein the inner core contains a medicament unstable to light and the outer layer contains a light-absorbing substance.
A method for improving photostability of a medicament unstable to light contained in an orally disintegrating tablet,
- the method comprising:
- forming the orally disintegrating tablet so that the orally disintegrating tablet comprises an inner core and an outer layer that covers the surface of the inner core;
- incorporating the medicament into the inner core;
- and
- incorporating a light-absorbing substance into the outer layer.
A method for improving photostability of a medicament unstable to light contained in an orally disintegrating tablet that comprises an inner core containing the medicament and an outer layer that covers the surface of the inner core, the method comprising incorporating a light-absorbing substance into the outer layer.
A method for stabilizing a medicament unstable to light, the method comprising coating a tablet containing the medicament with an outer layer containing a light-absorbing sub stance.
An orally disintegrating dry-coated tablet comprising an inner core and an outer layer that covers a surface of the inner core, wherein the inner core contains a medicament unstable to light and the outer layer contains a light-absorbing substance,
- wherein the thickness of the outer layer is 0.3 mm to 2 mm,
- wherein the weight of the inner core is 10 mg to 400 mg,
- wherein the weight of the outer layer is 50 mg to 800 mg,
- wherein the outer layer contains the light-absorbing substance in an amount of 0.01 to 600 mg/mm2 per unit surface are of the inner core,
- wherein the inner core further contains a disintegrating agent and the outer layer contains a disintegrating agent, and
- wherein the mean volume diameter of the light-absorbing substance is 0.01 to 1.0 μm.
Dependencies are inferred from the claim text.