Airway mucus impaction
AssigneesThe Regents of the University of California, Wisconsin Alumni Research Foundation
InventorsEleanor Dunican, John Fahy, Brett Elicker, John Newell, Scott Nagle, Mark Schiebler, David Gierada
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Abstract
Provided herein are, inter alia, methods and systems for detecting mucus in the lungs of a subject. Aspects provide methods and systems for the diagnosis, prognosis, characterization, detection, and treatment of asthma, chronic obstructive pulmonary disease, and type 2 inflammation.
Claims43
A method of treating a subject who has asthma or chronic obstructive pulmonary disease (COPD), the method comprising:
- detecting an airway mucus occlusion in a lung segment of the subject;
- and
- administering to the subject a therapeutically effective amount of a mucolytic agent or a type 2 inflammation inhibitor, wherein the subject has an airway mucus occlusion in at least one lung segment.
A method of treating a subject in need thereof, the method comprising administering a therapeutically effective amount of a mucolytic agent or a type 2 inflammation inhibitor to the subject, wherein the subject has an airway mucus occlusion in at least four lung segments.
A method of detecting type 2 inflammation in a subject, the method comprising:
- detecting an airway mucus occlusion in a lung segment of the subject;
- and
- identifying the subject as having type 2 inflammation if subject has an airway mucus occlusion in a lung segment.
A diagnostic method comprising detecting an airway mucus occlusion in a lung segment of a subject.
A method for identifying whether a subject is likely to respond or responsive to treatment with a mucolytic agent or a type 2 inflammation inhibitor, the method comprising:
- detecting an airway mucus occlusion in a lung segment of a subject;
- and
- identifying the subject as likely to respond or responsive to treatment with a mucolytic agent or a type 2 inflammation inhibitor if the subject has an airway mucus occlusion in a lung segment.
A method for identifying whether a subject is unlikely to respond, incompletely responsive, or unresponsive to treatment with an anticholinergic agent, a bronchodilator, or a corticosteroid, the method comprising:
- detecting an airway mucus occlusion in a lung segment of a subject;
- and
- identifying the subject as unlikely to respond, incompletely responsive, or unresponsive to treatment with an anticholinergic agent, a bronchodilator, or a corticosteroid if the subject has an airway mucus occlusion in a lung segment.
A system, comprising:
- a scanner configured to capture one or more lung images of a subject;
- at least one data processor;
- and
- at least one memory storing instructions which, when executed by the at least one data processor, result in operations comprising:
- determining, based at least on the one or more lung images, a quantification of mucus plugging for the subject;
- determining, based at least on the quantification of mucus plugging, a diagnosis for the subject, the diagnosis comprising a detection of an airway mucus occlusion in at least one lung segment of the subject;
- and
- identifying, based at least on the diagnosis, one or more treatments for the subject, the one or more treatments including a therapeutically effective amount of a mucolytic agent and/or a type 2 inflammation inhibitor.
Dependencies are inferred from the claim text.