Nutritional composition for improving cell membranes
AssigneeN.V. Nutricia
InventorsAnniek Lidewij Schipper, Eline Marleen VAN DER BEEK, Dennis Stanley ACTON, Nana BARTKE, Stefanie SCHOEN
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Abstract
An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.
Claims20
A method for improving the fatty acid composition of cell membranes in a human subject, the method comprising administering to the subject a nutritional composition comprising lipid in the form of lipid globules, wherein the lipid comprises
- (i) at least 0.5 wt. % alpha-linolenic acid based on total fatty acids,
- (ii) at least 5 wt. % linoleic acid based on total fatty acids,
- (iii) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 15 wt. % of the palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, and
- (v) at least 0.5 wt. % phospholipid based on total lipid, wherein a part of the phospholipid is in the coating of the lipid globule,
- wherein the lipid globules have a mode diameter based on volume of at least 1 μm and/or at least 45 vol. % have a diameter of 2-12 μm,
- wherein the nutritional composition is not human milk or comprises vegetable lipid, and
- wherein the cell membranes are brain cell membranes or red blood cell membranes.
A method for (i) improving cognitive performance and/or improving cognitive development and/or preventing cognitive impairment, (ii) improving behavioural performance and/or improving behavioural development, (iii) improving visual acuity, and/or (iv) improving fine motor skills by improving the fatty acid composition of brain cell membranes in a human subject, the method comprising administering to the subject a nutritional composition comprising lipid in the form of lipid globules, wherein the lipid comprises
- (i) at least 0.5 wt. % alpha-linolenic acid based on total fatty acids,
- (ii) at least 5 wt. % linoleic acid based on total fatty acids,
- (iii) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 15 wt. % of the palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, and
- (v) at least 0.5 wt. % phospholipid based on total lipid, wherein a part of the phospholipid is in the coating of the lipid globule,
- wherein the lipid globules have a mode diameter based on volume of at least 1 μm and/or at least 45 vol. % have a diameter of 2-12 μm, and
- wherein the nutritional composition is not human milk or comprises vegetable lipid.
A method for prevention and/or treatment of a disorder associated with impaired brain membrane fatty acid composition selected from the group consisting of consisting of attention deficiency, ADHD, autism, dyslexia, depression, bipolar depression, anxiety, schizophrenia, obsessive compulsive disorder, bulimia, abuse of alcohol or drugs, borderline personality disorder, panic disorder, social phobia, cognitive impairment, dementia, and Alzheimer's disease and Parkinson's disease by improving the fatty acid composition of brain cell membranes in a human subject, the method comprising administering to the subject a nutritional composition comprising lipid in the form of lipid globules, wherein the lipid comprises
- (i) at least 0.5 wt. % alpha-linolenic acid based on total fatty acids,
- (ii) at least 5 wt. % linoleic acid based on total fatty acids,
- (iii) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 15 wt. % of the palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, and
- (v) at least 0.5 wt. % phospholipid based on total lipid, wherein a part of the phospholipid is in the coating of the lipid globule,
- wherein the lipid globules have a mode diameter based on volume of at least 1 μm and/or at least 45 vol. % have a diameter of 2-12 μm, and
- wherein the nutritional composition is not human milk or comprises vegetable lipid.
Dependencies are inferred from the claim text.