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US 2019/0289834 A1Published application
Animal models for psoriasis and screening methods
AssigneeU.S. Goverment AS Represented By the Department of Veterans Affirs
InventorsM. Peter Marinkovich, Carl Gustaf Maarten Winge
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Abstract
A biologically relevant animal model for psoriasis is provided. Epidermal-immune interactions governing epidermal tissue homeostasis are altered in psoriasis, an inflammatory disease affecting one in thirty adults. Here, we characterize Rac1 as a key mediator of this process. Rac1 activation was consistently elevated in psoriatic epidermis and primary psoriatic human keratinocytes (PHKC).
Claims12
An animal model for psoriasis, in which keratinocytes have been modified to express activated Rac1, and where the animal mimics the phenotype of human psoriasis.
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