Recombinant oncolytic virus, synthetic dna sequence, and application thereof
AssigneeWuhan Boweid Biotechnology Co., Ltd.
InventorLigang Cai
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Abstract
The disclosure provides a recombinant oncolytic virus, a synthetic DNA sequence and applications of the virus. The recombinant oncolytic virus includes a genome and an exogenous DNA sequence inserted in the genome. The exogenous DNA sequence adapts to express a basic peptide fragment, to increase the environmental pH in a host infected by the recombinant oncolytic virus. The basic peptide fragment includes more than 60% of basic amino acids. The recombinant oncolytic virus and the synthetic DNA sequence of the disclosure are used to prepare an anti-tumor drug.
Claims28
A recombinant oncolytic virus, comprising:
- an oncolytic virus genome and an exogenous DNA sequence inserted in the oncolytic virus genome, the exogenous DNA sequence being adapted to express a basic peptide fragment and to increase an environmental pH in a host infected by the recombinant oncolytic virus.
A synthetic DNA sequence, the synthetic DNA sequence being adapted to express a basic peptide fragment comprising more than 60% of basic amino acids.
Dependencies are inferred from the claim text.