Back to results
US 2019/0282507 A1Published application
Celecoxib and amlodipine formulation and method of making the same
AssigneesDexcel Ltd., Kitov Pharmaceuticals Ltd.
InventorYitshak Itsik EFRATI
Life of this patent
Estimating the term…
Abstract
Provided herein is a celecoxib and amlodipine composition and method of making the same. The composition contains granules containing celecoxib. The amlodipine is incorporated into the composition as an extragranulate.
Claims16
1-10. (canceled)
A pharmaceutical composition comprising:
- (i) a dry granulate comprising celecoxib or a pharmaceutically acceptable salt, wherein the dry granulate has a loss on drying (LOD) % of about 2.5% or less, wherein said dry granulate does not include amlodipine;
- and
- (ii) an extragranulate comprising amlodipine or a pharmaceutically acceptable salt thereof;
- and optionally
- (iii) one or more excipients selected from the group consisting of a diluent, a disintegrant, a surfactant, a binder, a glidant, a lubricant, and combinations thereof.
2 more elements
A pharmaceutical composition comprising:
- a dry granulate comprising celecoxib or a pharmaceutically acceptable salt thereof and a diluent, a disintegrant, a binder, and a surfactant, wherein the dry granulate has a loss on drying (LOD) % of about 2.5% or less, wherein said dry granulate does not include amlodipine;
- and
- an extragranulate comprising either amlodipine or amlodipine besylate, and a diluent, a disintegrant, a glidant, and a lubricant.
Dependencies are inferred from the claim text.