Affenadenovirus (gorilla) or adenoviral vectors and methods of use
AssigneeGenVec, Inc.
InventorsDuncan McVey, Douglas E. Brough, Jason G.D. Gall
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Abstract
The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
Claims21
-105. (canceled)
A method of delivering a non-native nucleic acid sequence to mammalian cells in vivo, wherein the method comprises in vivo administration of an adenovirus or adenoviral vector comprising the non-native nucleic acid sequence and one or more of the nucleic acid sequences selected from the group consisting of:
- (a) a nucleic acid sequence that is at least 96% identical to SEQ ID NO:
- 1, (b) a nucleic acid sequence that is at least 99% identical to SEQ ID NO:
- 2, (c) a nucleic acid sequence that is at least 80% identical to SEQ ID NO:
- 3, (d) a nucleic acid sequence that is at least 80% identical to SEQ ID NO:
- 4;
- and (e) a nucleic acid sequence that is at least 85.4% identical to SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.