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US 2019/0269711 A1Published application
Methods of treating cancer
AssigneeAscend Biopharmaceuticals Ltd
InventorClement Leong
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AssigneeAscend Biopharmaceuticals Ltd
InventorClement Leong
Estimating the term…
The present invention relates to methods of treating cancer in a human subject in need thereof. In particular, the present invention relates to treating a cancer by administering a recombinant virus which expresses one or more biotherapeutic agents in a subject, and administering to the subject a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent. The invention further relates to method for treating cancer by administering a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent and a caspase inhibitor, and, optionally, also administering a recombinant virus expressing one or more biotherapeutic agents in the subject. The invention also relates to a method for treating cancer by administering purified interferon gamma to a subject and administering to the subject a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent. Also provided are pharmaceutical compositions, including controlled release pharmaceutical compositions containing: a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent and a recombinant virus; a nucleotide analogue or nucleotide analogue precursor chemotherapeutic agent and a caspase inhibitor; or a purified interferon gamma and a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent.
A method of treating a human subject suffering from a cancer, the method comprising:
Use of a recombinant virus which expresses one or more biotherapeutic agents in a human subject for the manufacture of a medicament for the treatment of a cancer in the human subject, wherein the human subject has been or will be administered a nucleotide analogue or a nucleotide precursor analogue chemotherapeutic agent.
Use of a nucleotide analogue or nucleotide precursor analogue chemotherapeutic agent for the manufacture of a medicament for the treatment of a cancer in a human subject, wherein the human subject has been or will be administered with a recombinant virus which expresses one or more biotherapeutic agents in the human subject.
A pharmaceutical composition for use in the treatment of a cancer, the pharmaceutical composition comprising:
Dependencies are inferred from the claim text.