Biomarkers for predicting degree of weight loss
AssigneeNestec S.A.
InventorsJorg Hager, Irina Irincheeva, Armand Valsesia, Wim Saris, Arne Astrup
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Abstract
A method for predicting the degree of weight loss attainable by applying one or more dietary interventions to a subject, said method comprising determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the biomarkers are selected from fructosamine and factor VII.
Claims28
A method for predicting the degree of weight loss attainable by applying one or more dietary interventions to a subject, said method comprising:
- determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the biomarkers are selected from fructosamine and factor VII.
The method according to claim 7, wherein the low calorie diet comprises a calorie intake of about 600 to about 1200 kcal/day.
The method according to claim 7, wherein the low calorie diet comprises administration of at least one diet product.
The method of claim 7, wherein the low calorie diet has a duration of 6 to 12 weeks.
A method for predicting the body mass index that a subject would be expected to attain from a dietary intervention (BMI2), wherein the method comprises:
- a. determining the level of fructosamine, Factor VII, adiponectin and insulin in one or more samples obtained from the subject;
- and
- b. predicting BMI2 using formula (1):
- bmi2 i=c1*bmi1i +c2(if subject I is female)+c3*agei−c4*factor VII i+c5*fructosamine i−c6*adiponectin i+c7*fasting insulin i (1)
- wherein BMI1 is the subject's body mass index before the dietary intervention and BMI2 is the subject's predicted body mass index after the dietary intervention;
- and
- wherein c1, c2, c3, c4, c5, c6, and c7 are positive integers.
A computer program product comprising computer implementable instructions for causing a programmable computer to predict the degree of weight loss given the levels of one or more biomarkers from the user, wherein the biomarkers are selected from fructosamine and factor VII.
A kit for predicting the degree of weight loss attainable by a subject following a dietary intervention, wherein said kit comprises:
- a. an antibody specific for factor VII;
- and
- b. an antibody specific for glycated albumin.
Dependencies are inferred from the claim text.