Use of Antibodies to TIMP-2 for the Improvement of Renal Function
AssigneesAstute Medical, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPAUL MCPHERSON, JOHN A. KELLUM
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Abstract
The invention provides methods for the treatment of subjects having or at risk of having kidney injuries using antibodies that specifically bind Metalloproteinase inhibitor 2 (TIMP-2). Specifically, the methods can be used for the treatment of a subject having chronic kidney disease (CKD), acute kidney injury (AKI), or a subject having an existing diagnosis of one or more of congestive heart failure, preeclampsia, eclampsia, diabetes mellitus, hypertension, coronary artery disease, proteinuria, glomerular filtration below the normal range, cirrhosis, serum creatinine above the normal range, sepsis, or acute renal failure (ARP).
Claims22
A method of improving kidney function in a subject in need thereof comprising administering to the subject an antibody that specifically binds Metalloproteinase inhibitor 2 (TIMP-2), optionally in association with one or more further therapeutic agents or therapeutic procedures indicated for the improvement of kidney function, in an amount sufficient to improve kidney function.
Dependencies are inferred from the claim text.