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US 2019/0254302 A1Published application
Systems and methods for controlling the release from enzyme-responsive microcapsules with a smart natural shell
OwnerAlireza ABBASPOURRAD, Raheleh RAVANFARinventors
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Abstract
The present application relates to a microcapsule comprising a core comprising one or more hydrophobic agents dispersed in a gel matrix; a proteolytically-cleavable outer polymer shell surrounding said core; and an enzymatically-cleavable lipid layer between said core and said shell. Also described are methods of making and using the microcapsules.
Claims26
A microcapsule comprising:
- a core comprising one or more hydrophobic agents dispersed in a gel matrix;
- a proteolytically-cleavable outer polymer shell surrounding said core;
- and
- an enzymatically-cleavable lipid layer between said core and said shell.
1 more element
A method of preparing a microcapsule, said method comprising:
- dispersing one or more hydrophobic agents into an aqueous solution of a hydrophilic non-ionic surfactant and a gel matrix to produce an oil-in-water (o/w) single emulsion;
- mixing the o/w single emulsion with one or more lipids to produce an oil-in-water-in-oil (o/w/o) double emulsion;
- blending the o/w/o double emulsion with a secondary aqueous solution to produce an oil-in-water-in-oil-in-water (o/w/o/w) triple microemulsion;
- drying the o/w/o/w triple microemulsion to form a dried triple microemulsion;
- and
- incubating the dried triple microemulsion to form microcapsules each comprising one or more hydrophobic agents in a hydrophilic aqueous core surrounded by a proteolytically-cleavable outer polymer shell with an enzymatically-cleavable lipid layer between said core and said shell.
3 more elements
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Dependencies are inferred from the claim text.