Adsorptive membranes for trapping viruses
AssigneeWisconsin Alumni Research Foundation
InventorMark R. Etzel
Life of this patent
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Abstract
A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic charge repulsion.
Claims21
1-22. (canceled)
A method of removing viruses from a solution suspected of containing viruses, the method comprising contacting the solution with a disposable, virus-trapping membrane for a time sufficient to a yield log-reduction value (LRV) of at least 1.0 for viruses disposed in the solution, wherein the virus-trapping membrane comprises:
- a micro-porous filter membrane;
- and
- a multi-modal anion-exchange ligand that has a pKa sufficiently high to repel basic proteins via electrostatic charge repulsion immobilized on the filter membrane, wherein the ligand comprises one or more of tyrosinol, tryptophanol, octopamine, 1,3-diamino-2-hydroxypropane, tris(2-aminoethyl)amine, and agmatine.
Dependencies are inferred from the claim text.