Mitochondrial proteins constructs and uses thereof
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsHaya Lorberboum-Galski, Hagar Greif
Life of this patent
Estimating the term…
Abstract
Disclosed are novel fusion protein constructs comprising a functional mitochondrial protein, that can enter mitochondria within intact cells. Further disclosed are methods of treating mitochondrial disorders by the disclosed fusion proteins and compositions therefor.
Claims8
A fusion protein comprising an HIV-1 transactivator of transcription (TAT) domain fused to a human pyruvate dehydrogenase E1 component alpha subunit (PDHE1a) and a human mitochondria targeting sequence (MTS), wherein the MTS is situated between the TAT domain and the PDHE1a, the PDHE1a is C-terminal to the MTS, and the MTS is heterologous to the PDHE1a.
Dependencies are inferred from the claim text.