Pharmaceutical composition for preventing or treating ischemia-reperfusion injury, containing bile acid
AssigneeSamsung Life Public Welfare Foundation
InventorsHyeon Cheol GWON, Hyung Suk JANG
Life of this patent
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Abstract
The present invention relates to a composition for preventing, treating, or alleviating ischemia-reperfusion injury, containing bile acid. According to the present invention, bile acid increases intranuclear beta-catenin levels, interferes with the opening of a mitochondria permeable transition pore (mPTP), and has excellent effects, in ischemia-reperfusion injury animal models, of alleviating tissue injury and reducing the size of infarcts, thereby being usable in the prevention, treatment, or alleviation of ischemia-reperfusion injury.
Claims19
A pharmaceutical composition for preventing or treating ischemia-reperfusion injury, the composition comprising a bile acid or pharmaceutically acceptable salt thereof.
A method of preventing or treating ischemia-reperfusion injury, the method comprising:
- administering a bile acid or pharmaceutically acceptable salt thereof to a subject in need thereof.
A food composition for preventing or ameliorating ischemia-reperfusion injury, the composition comprising a bile acid or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.