Antimicrobial wound care dressing
AssigneeOhio State Innovation Foundation
InventorsShaurya PRAKASH, Vishwanath V. SUBRAMANIAM, Molly Marie BENNETT, Chandan K. SEN, Travis Hamilton JONES, Emily Quinn ROSENTHAL, Shomita STEINER, Sashwati ROY, Joseph Dean WEST, Piya Das GHATAK
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Abstract
Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.
Claims76
An antimicrobial dressing for a wound comprising:
- a substrate;
- at least one pair of electrodes positioned on or within the substrate, wherein the pair of electrodes comprise a conductive anode in contact with at least a first portion of the wound and a conductive cathode in contact with at least a second portion of the wound;
- and
- an energy source connected to at least one electrode pair, wherein the energy source induces an electrical current to flow from the conductive anode, through the wound, to the conductive cathode.
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The antimicrobial dressing of claim 40, wherein a first subset of the plurality of electrodes are connected in electrical series with the anode and a second set of the plurality of electrodes are connected in electrical series with the cathode and the plurality of electrodes are comprised of a biocompatible reduction/oxidation reaction material such that a voltage differential is created between the anode and the cathode, wherein said voltage differential causes the electrical current to flow from the conductive anode, through the wound, to the conductive cathode.
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A method of treating a bacterial infection in a wound, the method comprising:
- applying an antimicrobial dressing to the wound;
- and
- applying a therapeutically effective amount of an electric current to the wound from the antimicrobial dressing.
A method of assembling an antimicrobial dressing, comprising:
- applying a layer of conductive material to an insulated base substrate to form at least one electrode pair on the insulated base substrate, wherein the pair of electrodes comprise a conductive anode and a conductive cathode that are electrically insulated from one another,
- wherein an energy source is connected to the at least one electrode pair, wherein the energy source induces an electrical current to flow from the conductive anode, through a wound, to the conductive cathode.
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Dependencies are inferred from the claim text.