Antibodies that bind notum pectinacetylesterase
AssigneeLexicon Pharmaceuticals, Inc.
InventorsRobert Joseph Brommage, JR., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
Life of this patent
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Abstract
Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
Claims10
-29. (canceled)
A method of stimulating endocortical bone formation in a patient, comprising administering an effective amount of a pharmaceutical composition comprising a monoclonal antibody that binds to human notum pectinacetylesterase (NOTUM) and neutralizes at least one activity of NOTUM.
A method of treating, managing, or preventing a disease or disorder characterized by bone loss in a patient, comprising administering an effective amount of a pharmaceutical composition comprising a monoclonal antibody that binds to human notum pectinacetylesterase (NOTUM) and neutralizes at least one activity of NOTUM.
Dependencies are inferred from the claim text.