Inhibitors of Staphylococcus pseudintermedius Sortase
OwnerDavid Bemis, Stephen Kania +2inventors
InventorsDavid Bemis, Stephen Kania, Jerome Baudry, Manasi Balachandran
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Abstract
Compounds inhibitory to Staphylococcus pseudintermedius Sortase A (SrtA) are identified. The compounds inhibit cell wall-associated protein anchoring to the bacterial cell wall, thus potentially reducing bacterial virulence.
Claims8
A method for reducing virulence of a Staphylococcus pseudintermedius organism, comprising exposing the organism to at least one inhibitor of S. pseudintermedius sortase A.
Recombinant S. pseudintermedius sortase A protein, comprising the amino acid sequence set forth as SEQ ID NO:
- 2.
A therapeutic composition adapted to inhibit virulence of a S. pseudintermedius organism, comprising:
- at least one inhibitor of S. pseudintermedius sortase A;
- and a
- pharmaceutically or veterinary acceptable carrier.
Dependencies are inferred from the claim text.