Methods of inhibiting metastasis in cancer
AssigneeWisconsin Alumni Research Foundation
InventorsPAMELA KAY KREEGER, MOLLY JANE CARROLL, KAITLIN C. FOGG
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Abstract
As described herein, a method of inhibiting metastasis in cancer includes administering to a human subject diagnosed with a cancer of an organ of the peritoneal cavity a therapeutically effective amount of an inhibitor of CCR5 or P-selectin. Preferably the subject has a tumor positive for a ligand of P-selectin such as a CD24+ or PSGL-1+ tumor. Analysis of samples from HGSOC patients confirmed increased MIP-1β and P-selectin, suggesting that this novel multi-cellular mechanism can be targeted to slow or stop metastasis in cancers such as high-grade serous ovarian cancer, for example by using anti-CCR5 and P-selectin therapies developed for other indications.
Claims16
A method of inhibiting metastasis in cancer, comprising administering to a human subject diagnosed with a cancer of an organ of the peritoneal cavity a therapeutically effective amount of an inhibitor of CCRS or P-selectin, wherein the subject has a tumor positive for a ligand of P-selectin such as a CD24+ or PSGL-1+ tumor.
Dependencies are inferred from the claim text.