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US 2019/0241659 A1Published application
Bispecific fusion polypeptides and methods of use thereof
OwnerJohn Mumm, Yue Wang +8inventors
InventorsJOHN MUMM, YUE WANG, RYAN GILBRETH, RONALD HERBST, SCOTT HAMMOND, MICHAEL OBERST, GODFREY JONAH RAINEY, SIMON DOVEDI, JONATHAN SEAMAN, MICHELLE TURNHAM
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Abstract
Provided herein are bispecific fusion proteins and methods of using the bispecific fusion proteins for treating cancer.
Claims38
A bispecific fusion protein, comprising:
- a single chain fusion protein comprising a first binding region specific for a first cell surface target, an Fc monomer, and a second binding region specific for a second cell surface target,
- wherein the first binding region and the second binding region are covalently linked to the Fc monomer via a peptide linker, and
- wherein the bispecific fusion protein is capable of binding the first cell surface target and the second cell surface target at the same time.
Dependencies are inferred from the claim text.