Therapeutic mRNAs encoding anti CTLA-4 antibodies

A polynucleotide comprising one or more mRNAs which encode an antibody or an antigen binding portion thereof which specifically binds to CTLA-4 and which specifically binds to the same CTLA-4 epitope as:

• (i) an antibody or antigen-binding portion thereof comprising a heavy chain variable region (VH) of SEQ ID NO:
• 9, 28, or 39, and a light chain variable region (VL) of SEQ ID NO:
• 11, 29 or 41, or
• (ii) an antibody or antigen-binding portion comprising a VH of SEQ ID NO:
• 183 or SEQ ID NO:
• 240 and a VL of SEQ ID NO:
• 185 or SEQ ID NO:
• 238.

A polynucleotide comprising one or more mRNAs which encode an antibody or an antigen binding portion thereof which specifically binds to CTLA-4, and which comprises a VL and a VH, wherein

• (i) the VL comprises an amino acid sequence having at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% sequence identity to SEQ ID NO:
• 11, SEQ ID NO:
• 29, or SEQ ID NO:41, and the VH comprises an amino acid sequence having at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% sequence identity to SEQ ID NO:
• 9, SEQ ID NO:
• 28, or SEQ ID NO:39;
• or,
• (ii) the VL comprises an amino acid sequence having at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% sequence identity to SEQ ID NO:
• 185 or SEQ ID NO:
• 238, and the VH comprises an amino acid sequence having at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% sequence identity to SEQ ID NO:
• 183 or SEQ ID NO:
• 240.