Insulin analogs
AssigneesUniversity of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical Research
InventorsJohn Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Olivera M. BALDOMERO
Life of this patent
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Abstract
The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
Claims22
1-94. (canceled)
A peptide comprising an A chain and a B chain,
- wherein the A chain has the sequence GIVEQCCA8A9ICSLYQLENYCA21, and
- wherein the B chain and has the sequence FVNQHLCGSB10LVEALYLVCB20ER,
- wherein:
- A8 is selected from the group consisting of histidine, tyrosine, and lysine;
- A9 is arginine;
- A21 is selected from the group consisting of asparagine and glycine;
- B10 is selected from the group consisting of glutamic acid, aspartic acid, and glutamine;
- and
- B20 is selected from the group consisting of tyrosine, phenylalanine, and proline.
Dependencies are inferred from the claim text.