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US 2019/0241639 A1Published application
Fusion protein for treating intestinal diseases
AssigneeZhejiang Doer Biologics Corporation
InventorsXIAOFANG WEN, YANSHAN HUANG, ZHIYU YANG, GAOFENG YAO, YONGLU CHEN, XUELIAN WANG
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Abstract
The invention provides fusion proteins for treating an intestinal disease, having a structure as follows: R-L-P, wherein R is a GLP-2 receptor agonist; L is a peptide linker; and P is a long-acting carrier protein. The fusion protein provided by the invention has significant bioactivities and in vitro stability.
Claims14
A fusion protein, wherein the structure characterized as follows:
- R-L-P
- wherein R is a GLP-2 receptor agonist;
- P is a long-acting carrier protein;
- and
- L is a peptide linker and is represented by the following formula:
- (XSSGAPPPS)u-G/S-(G-W1-W2)m,
- wherein X is selected from a group consisting of P, GP, GGP and NGGP;
- G/S is a peptide consisting of G and S in arbitrary combination and with 5 to 25 amino acids in length;
- W1 and W2 are selected from a group consisting of 19 natural amino acid residues except Cys, respectively;
- u is 0 or 1;
- and m is an integer of 1 to 20.
8 more elements
Dependencies are inferred from the claim text.