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US 2019/0241570 A1Published application
Novel dihydropyrrolopyrimidines for the treatment and prophylaxis of hepatitis b virus infection
AssigneeHoffmann-La Roche Inc.
InventorsZhanling Cheng, Xingchun Han, Min Jiang, Song Yang
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Abstract
The present invention provides novel compounds having the general formula: wherein R1, R2, A and X are as described herein, compositions including the compounds and methods of using the compounds.
Claims22
A compound of formula I,
- wherein:
- R1 is aminoC1-6alkyl, C1-6alkyl, C3-7cycloalkyl, carboxyC1-6alkyl, cyanoC1-6alkyl, haloC1-6alkyl, hydrogen or hydroxyC1-6alkyl;
- R2 is phenyl, naphthyl, or heteroaryl, wherein said phenyl, naphthyl and heteroaryl are unsubstituted or substituted with one, two or three substituents independently selected from 2-oxa-6-azaspiro[3.3]heptanyl, azetidinyl, C1-6alkoxy, C1-6alkyl, C1-6alkylamino, C1-6alkylcarbonylpiperazinyl, C1-6alkylsulfonylpiperazinyl, diC1-6alkylamino, haloC1-6alkyl, halogen, morpholinyl, nitro, oxopiperazinyl, piperazinyl, piperidinyl and pyrrolidinyl;
- A is N or CH;
- and
- X is a bond or —C(═O)—;
- or a pharmaceutically acceptable salt, or enantiomer, or diastereomer thereof.
4 more elements
(canceled)
-23. (canceled)
(canceled)
Dependencies are inferred from the claim text.