Process for preparation of palbociclib
AssigneeDr. Reddy's Laboratories, Inc.
InventorsAndiappan MURUGAN, Vipinkumar Shriram KABRA, Chinna Saida Reddy GADE, Rama Rao GONDU, Shravankumar CHANDRASHEKAR, Krishnamoorthy PASUPATHY, Anandan KALAISELVAN
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Abstract
The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m2/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m2/g.
Claims10
One-pot process for the preparation of compound of formula (IV) comprising the steps of:
- (a) reacting compound of formula (I) with a compound of formula (II) to provide compound of formula (III)
- (b) reacting compound of formula (III) with n-butyl vinyl ether to provide compound of formula (IV)
Dependencies are inferred from the claim text.