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US 2019/0241560 A1Published application
Bicyclic heterocycles as fgfr4 inhibitors
AssigneeIncyte Corporation
InventorsLiang Lu, Liangxing Wu, Ding-Quan Qian, Wenqing Yao
Life of this patent
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Abstract
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.
Claims31
1-39. (canceled)
A method of treating cancer in a patient comprising administering to said patient a therapeutically effective amount of a compound selected from:
- N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-[2,7]naphthyridin]-6′-yl]methyl}acrylamide;
- N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)methyl)acrylamide;
- N-((3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(pyridin-3-yl)-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)methyl)acrylamide;
- and
- N-((6′-(2,6-difluoro-3,5-dimethoxyphenyl)-7′-oxo-6′,7′-dihydro-5′H-spiro[cyclopropane-1,8′-pyrido[4,3-d]pyrimidine]-2′-yl)methyl)acrylamide;
- or a pharmaceutically acceptable salt thereof.
3 more elements
(canceled)
Dependencies are inferred from the claim text.