# US 2019/0241554 A1 · 1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin d synthase inhibitors

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- Number: US 2019/0241554 A1
- Document ID: US20190241554A1
- Status: Published application
- Kind: A1
- Application number: 16/341,113
- Filed: 2017-10-12
- Published: 2019-08-08
- Earliest claimed: 2016-10-13
- Assignees: GlaxoSmithKline Intellectual Property Development Limited
- Applicants: GlaxoSmithKline Intellectual Property Development Limited
- Inventors: David Norman DEATON; Yu GUO; Ashley Paul HANCOCK; Christie SCHULTE; Barry George SHEARER; Emilie Despagnet SMITH; Eugene L. STEWART; Stephen Andrew THOMSON
- Web page: https://patentgrep.com/patent/US20190241554A1

## CPC

- C07D 417/14: containing three or more hetero rings
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61P 11/06: Antiasthmatics
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- C07C 235/40: having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07D 205/04: having no double bonds between ring members or between ring members and non-ring members
- C07D 215/24: attached in position 8
- C07D 239/42: One nitrogen atom (nitro radicals C07D239/30)
- C07D 239/72: Quinazolines; Hydrogenated quinazolines
- C07D 257/06: with nitrogen atoms directly attached to the ring carbon atom
- C07D 271/10: 1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D 277/44: Acylated amino or imino radicals
- C07D 277/62: Benzothiazoles
- C07D 277/64: with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 403/04: directly linked by a ring-member-to-ring-member bond
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 471/04: Ortho-condensed systems
- C07C 2601/02: with a three-membered ring
- C07C 2601/04: with a four-membered ring
- C07C 2601/14: The ring being saturated
- C07C 2602/08: the other ring being five-membered, e.g. indane
- C07C 2603/94: containing "free" spiro atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

## Claims

### Claim 1

A compound according to Formula (I)
wherein:
X is selected from: carbon and nitrogen;
Y is selected from: hydrogen and CH3;
Y1 is absent or CH3;
Z is NH or O;
a is 0 or 1;
R is selected from: O, NH, CH2 and C1alkyl substituted by halogen;
R1 is selected from:
aryl,
aryl substituted from 1 to 4 times by Ra,
heteroaryl,
heteroaryl substituted from 1 to 4 times by Ra,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 4 times by Ra;
R2 is selected from: O and S;
R3 is selected from:
aryl,
aryl substituted from 1 to 4 times by Rb,
cycloalkyl,
cycloalkyl substituted from 1 to 4 times by Rb,
heterocycle,
heterocycle substituted from 1 to 4 times by Rb,
heteroaryl,
heteroaryl substituted from 1 to 4 times by Rb,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 4 times by Rb;
each Ra is independently selected from:
fluoro,
chloro,
bromo,
iodo,
—OH,
C1-6alkyl,
C1-6alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-lalkyloxy, —OH, C1-4alkyl, oxo, —COOH, —NO2, —NH2 and —CN, cyano,
—OC1-6alkyl,
—OC1-6alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4aalkyloxy, —OH, C1-4alkyl, oxo, —COOH, —NO2, —NH2 and —CN,
cyano,
—C(O)OC1-6alkyl, and
—C(O)OC1-6alkyl substituted 1 to 5 times by fluoro;
each Rb is independently selected from:
cyano,
fluoro,
chloro,
bromo,
iodo,
C1-6alkyl,
Re,
—OC1-6alkyl,
—ORe,
oxo,
hydroxyl,
cycloalkyl,
cycloalkyl substituted from 1 to 4 times by Rf,
amino,
—NHRx,
where Rx is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OC1-6alkyl, —OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, and —OH, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —OC1-6alkyl, —COOH, —NH2, —NHcycloalkyl, and —CN,
heteroaryl,
heteroaryl substituted from 1 to 4 times by Rf,
heterocycle,
heterocycle substituted from 1 to 4 times by Rf,
—SO2H, and
—SO2C1-6alkyl;
each Rf is independently selected from:
fluoro,
chloro,
bromo,
iodo,
C1-6alkyl,
Re,
oxo,
—OH,
amino,
—NHRx1,
where Rx1 is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —OC1-6alkyl, —COOH, —NH2, and —CN,
−NRx2Rx3,
where Rx2 and Rx3 are each independently selected from: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN,
nitro, and
cyano, and
each Re is independently selected from:
C1-6alkyl substituted with from 1 to 9 substituents independently selected from:
fluoro,
chloro,
bromo,
iodo,
C1-6alkyl,
—OC1-6alkyl,
—OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, —CN, and phenyl,
oxo,
═N,
hydroxyl,
amino,
—NHRxx, or ═NRxx,
where Rxx is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —OC1-5alkyl, —OC1-5alkyl substituted from 1 to 6 times by fluoro,
—NRxx1,Rxx2,
where Rxx1 and Rxx2 are each independently selected from: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN,
aryl,
aryl substituted from 1 to 4 times by Rxx3,
where Rxx3 is selected from: fluoro, chloro, bromo, iodo, C1-6alkyl, C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN, —OC1-5alkyl, and —OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN,
cycloalkyl,
cycloalkyl substituted from 1 to 4 times by Rxx4,
where Rxx4 is selected from: fluoro, chloro, bromo, iodo, C1-6alkyl, C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN, —OC1-5alkyl, and —OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN,
nitro, and
cyano;
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1 represented by the following Formula (II):
wherein:
X1 is selected from: carbon and nitrogen;
Y10 is selected from: hydrogen and CH3;
Y11 is absent or CH3;
Z1 is NH or O;
a1 is 0 or 1;
R10 is selected from: O, NH, CH2 and C1alkyl substituted by halogen;
R11 is selected from:
aryl,
aryl substituted from 1 to 3 times by Ra1,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 3 times by Ra1;
R12 is selected from: O and S;
R13 is selected from:
aryl,
aryl substituted from 1 to 3 times by Rb1,
cycloalkyl,
cycloalkyl substituted from 1 to 3 times by Rb1,
heterocycle,
heterocycle substituted from 1 to 3 times by Rb1,
heteroaryl,
heteroaryl substituted from 1 to 3 times by Rb1,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 3 times by Rb1;
each Ra1 is independently selected from:
fluoro,
chloro,
bromo,
iodo,
C1-4alkyl,
C1-4alkyl substituted with from 1 to 4 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4 alkyloxy, —OH, oxo, and —COOH,
—OC1-6alkyl,
—OC1-6alkyl substituted with from 1 to 4 substituents independently selected from: fluoro, chloro, bromo, iodo, C1-4alkyloxy, —OH, oxo, and —COOH, and
—C(O)OC1-3alkyl;
each Rb1 is independently selected from:
cyano,
fluoro,
chloro,
C1-6alkyl,
Re1,
—OC1-6alkyl,
—ORe1,
oxo,
hydroxyl,
cycloalkyl,
cycloalkyl substituted by Rf1
amino,
—NHRx10
where Rx10 is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OC1-6alkyl, —OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, and —OH, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —OC1-6alkyl, —COOH, —NH2, —NHcycloalkyl, and —CN,
heteroaryl,
heteroaryl substituted from 1 to 4 times by Rf1,
heterocycle,
heterocycle substituted from 1 to 4 times by Rf1, —SO2H, and —SO2C1-6alkyl;
each Rf1 is independently selected from:
fluoro,
chloro,
bromo,
iodo,
C1-6alkyl,
Re1,
oxo,
—OH,
amino,
—NHRx11,
where Rx11 is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —OC1-6alkyl, —COOH, —NH2, and —CN,
—NRx12 Rx13,
where Rx12 and Rx13 are each independently selected from: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, and —COOH,
nitro, and
cyano; and
each Re1 is independently selected from:
C1-6alkyl substituted with from 1 to 9 substituents independently selected from:
fluoro,
chloro,
C1-6alkyl,
—OC1-6alkyl,
—OC1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and phenyl,
oxo,
═N,
hydroxyl,
amino,
—NHRxx10, or ═NRxx10,
where Rxx10 is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, C1-3alkyl, and C1-3alkyl substituted with from 1 to 4 substituents independently selected from: fluoro, oxo, —OH, —COOH, —OC1-5alkyl, —OC1-5alkyl substituted from 1 to 4 times by fluoro,
—NRxx11Rxx12,
where Rxx11 and Rxx12 are each independently selected from: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-6alkyl, and C1-6alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, and —OH,
aryl,
aryl substituted from 1 to 4 times by Rxx13,
where Rxx13 is selected from: fluoro, chloro, bromo, iodo, C1-3alkyl, C1-3alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN, —OC1-3alkyl, and —OC1-6alkyl substituted from 1 to 6 times by fluoro,
cycloalkyl, and
cycloalkyl substituted from 1 to 4 times by Rxx14,
where Rxx14 is selected from: fluoro, chloro, bromo, iodo, C1-3alkyl, C1-3alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —COOH, —NH2, and —CN, and —OC1-5alkyl;
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The compound of claim 1 represented by the following Formula (III):
wherein:
X2 is selected from: carbon and nitrogen;
y20 is selected from: hydrogen and CH3;
Y21 is absent or CH3;
Z2 is NH or O;
a2 is 0 or 1;
R2° is selected from: O, NH, CH2 and C1alkyl substituted by halogen;
R21 is selected from:
aryl,
aryl substituted from 1 to 3 times by Ra2,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 3 times by Ra2;
R22 is selected from: O and S;
R23 is selected from:
aryl,
aryl substituted from 1 to 3 times by Rb2,
cycloalkyl,
cycloalkyl substituted from 1 to 3 times by Rb2,
heterocycle,
heterocycle substituted from 1 to 3 times by Rb2,
heteroaryl,
heteroaryl substituted from 1 to 3 times by Rb2,
bicycloheteroaryl, and
bicycloheteroaryl substituted from 1 to 3 times by Rb2;
each Ra2 is independently selected from:
fluoro,
chloro,
bromo,
iodo,
C1-3alkyl,
C1-3alkyl substituted 1 to 4 times by fluoro,
—OC1-3alkyl, and
—OC1-3alkyl substituted 1 to 4 times by fluoro;
each Rb2 is independently selected from:
cyano,
C1-6alkyl,
Re2,
—OC1-4alkyl,
—ORe2,
oxo,
hydroxyl,
cycloalkyl,
amino,
—NHRx20,
where Rx20 is selected from heteroaryl, OC1-6alkyl, —OC1-6alkyl substituted 1 to 4 times by fluoro, C1-6alkyl, and C1-6alkyl substituted with from 1 to 4 substituents independently selected from: fluoro, oxo, —OH, —OC1-6alkyl, —NH2, and —NHcycloalkyl,
heteroaryl,
heteroaryl substituted from 1 to 3 times by Rf2,
heterocycle,
heterocycle substituted from 1 to 3 times by Rf2,
—SO2H, and
—SO2C1-6alkyl;
each Rf2 is independently selected from:
fluoro,
chloro,
C1-4alkyl,
Re2,
oxo,
amino,
—NHRx21,
where Rx21 is selected from C1-4alkyl, and C1-4alkyl substituted by —OC1-6alkyl,
—NRx22Rx23,
where Rx22 and Rx23 are each independently selected from: C1-4alkyl, and C1-6alkyl substituted 1 to 4 times by fluoro, and
cyano; and
each Re2 is independently selected from:
C1-4alkyl substituted with from 1 to 4 substituents independently selected from:
fluoro,
—OC1-4alkyl,
—OC1-4alkyl substituted by phenyl,
oxo,
═N,
hydroxyl,
amino,
—NHRxx20, or ═NRxx20,
where Rxx20 is selected from cyano, C1-3alkyl, and C1-3alkyl by —OC1-5alkyl,
—NRxx21Rxx22,
where Rxx21 and Rxx22 are each independently selected from: C1-4alkyl,
aryl,
aryl substituted by —OC1-3alkyl, and
cycloalkyl;
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

The compound of claim 1 represented by the following Formula (IV):
wherein:
X3 is selected from: carbon and nitrogen;
Y30 is selected from: hydrogen and CH3;
Y31 is absent or CH3;
Z3 is NH or O;
a3 is 0 or 1;
R30 is selected from: O, NH, CH2 and C1alkyl substituted by halogen;
R31 is selected from:
phenyl,
phenyl substituted from 1 to 3 times by Ra3,
benzothiazolyl,
benzothiazolyl substituted from 1 to 3 times by Ra3,
quinolinyl,
quinolinyl substituted from 1 to 3 times by Ra3,
thienopyridinyl,
thienopyridinyl substituted from 1 to 3 times by Raa3,
benzofuranyl,
benzofuranyl substituted from 1 to 3 times by Ra3,
quinazolinyl,
quinazolinyl substituted from 1 to 3 times by Ra3,
benzoimidazolyl,
benzoimidazolyl substituted from 1 to 3 times by Ra3,
imidazopyridinyl,
imidazopyridinyl substituted from 1 to 3 times by Ra3,
benzoisothiazolyl, and
benzoisothiazolyl substituted from 1 to 3 times by Ra3;
R32 is selected from: O and S;
R33 is selected from:
cyclohexyl,
cyclohexyl substituted from 1 to 3 times by Rb3,
tetrazolyl,
tetrazolyl substituted from 1 to 3 times by Rb3,
azetidinyl,
azetidinyl substituted from 1 to 3 times by Rb3,
cyclobutanyl,
cyclobutanyl substituted from 1 to 3 times by Rb3,
thiazolyl,
thiazolyl substituted from 1 to 3 times by Rb3,
oxadiazolyl,
oxadiazolyl substituted from 1 to 3 times by Rb3,
piperidinyl,
piperidinyl substituted from 1 to 3 times by Rb3,
pyrimidinyl,
pyrimidinyl substituted from 1 to 3 times by Rb3,
indolinyl,
indolinyl substituted from 1 to 3 times by Rb3,
tetrahydroquinolinyl,
tetrahydroquinolinyl substituted from 1 to 3 times by Rb3,
pyridinyl,
pyridinyl substituted from 1 to 3 times by Rb3,
tetrahydropyranyl,
tetrahydropyranyl substituted from 1 to 3 times by Rb3,
pyrrolidinyl,
pyrrolidinyl substituted from 1 to 3 times by Rb3,
spiroheptanyl,
spiroheptanyl substituted from 1 to 3 times by Rb3,
morpholinyl,
morpholinyl substituted from 1 to 3 times by Rb3,
indolinyl,
indolinyl substituted from 1 to 3 times by Rb3,
azaspiroheptanyl,
azaspiroheptanyl substituted from 1 to 3 times by Rb3,
oxazolyl,
oxazolyl substituted from 1 to 3 times by Rb3,
thiadiazolyl,
thiadiazolyl substituted from 1 to 3 times by Rb3,
triazolyl,
triazolyl substituted from 1 to 3 times by Rb3,
dihydroindenyl,
dihydroindenyl substituted from 1 to 3 times by Rb3,
2-azaspiro[3.3]heptane,
2-azaspiro[3.3]heptane substituted from 1 to 3 times by Rb3,
pyridazinyl,
pyridazinyl substituted from 1 to 3 times by Rb3,
pyrazinyl,
pyrazinyl substituted from 1 to 3 times by Rb3,
thiophenyl,
thiophenyl substituted from 1 to 3 times by Rb3,
tetrahydrothiophenyl,
tetrahydrothiophenyl substituted from 1 to 3 times by Rb3,
furanyl, and
furanyl substituted from 1 to 3 times by Rb3;
each Ra3 is independently selected from:
fluoro,
chloro,
bromo,
—CH3,
—CH2CH3,
—OCH3,
—OCF3, and
—OCHF2;
each Rb3 is independently selected from:
—C(OH)(CH3)2,
—CH2CH2CH2CH3,
—CH3,
—OH
cyano,
—OCH2CH(OH)cyclopropyl,
—OCH2C(CH3)(OH)cyclopropyl,
—CH2OH,
NH2,
—CH2CHF2,
—C(CH3)3,
—NHCH(CF3)CH2OH,
—CH(CH3)CHF2,
NHCH(CH3)CHF2,
oxo,
—CH(CH3)OH,
—CH(OH)cyclopropyl,
—C(CH3)(CF3)OH,
—C(O)OCH2CH3,
—C(O)cyclopropyl,
—OCH2C(OH)(CH3)2,
—C(O)CH3,
—OCH2CH2OCH3,
—C(NHCH3)Ncyano,
—NHC(O)OC(CH3)3,
—NHC(O)NHcyclohexyl,
—NHCpyrimidinyl,
—CH(CH3)CF3,
—C(O)OCH2phenyl,
—C(O)NHtetrahydropyran,
—CH2CF3,
—C(O)OCH3,
—C(O)OC(CH3)3,
—S(O)2CH3,
cyclopropyl,
—OCH3,
—CH2(chloro
—methoxyphenyl),
—C(O)N(CH3)2,
—NHCH(CF3)CH3,
—NHC(CH3)(OH)CHF2,
—C(O)NH2,
—C(O)OH,
—C(O)NH(CH3),
—CH(CH3)2,
—CF3,
—C(CH2)CH3,
—CH2C(OH)(CH3)2,
—C(O)CH2CH3,
fluoro,
—CH2C(O)CH2CH3,
CH2C(O)OCH2CH3,
thiazolyl,
thiazolyl substituted 1 or 2 times by Rf3,
pyrimidinyl,
pyrimidinyl substituted 1 or 2 times by Rf3,
pyridinyl,
pyridinyl substituted 1 or 2 times by Rf3,
azetidinyl,
azetidinyl substituted 1 or 2 times by Rf3,
oxazolyl,
oxazolyl substituted 1 or 2 times by Rf3.
oxadiazolyl,
oxadiazolyl substituted 1 or 2 times by Rf3,
isothiazolidinyl,
isothiazolidinyl substituted 1 or 2 times by Rf3,
imidazolidinyl,
imidazolidinyl substituted 1 or 2 times by Rf3,
oxooxazolidinyl,
oxooxazolidinyl substituted 1 or 2 times by Rf3,
morpholinyl,
morpholinyl substituted 1 or 2 times by Rf3,
tetrazolyl,
tetrazolyl substituted 1 or 2 times by Rf3,
pyrazinyl,
pyrazinyl substituted 1 or 2 times by Rf3,
pyridazinyl,
pyridazinyl substituted 1 or 2 times by Rf3,
pyrazolyl,
pyrazolyl substituted 1 or 2 times by Rf3,
thiophenyl, and
thiophenyl substituted 1 or 2 times by Rf3; and
each Rf3 is independently selected from:
cyano,
—C(NH)OCH3,
—C(O)NH2,
fluoro,
chloro,
—C(O)NH2,
—C(O)NHCH3,
—CH3,
—C(O)OCH3,
—C(O)CH3,
—C(O)OCH2CH3,
—C(OH)(CH3)2,
—NHCH(CH3)2,
—NHCH2CH2OCH3,
—N(CH3)2,
oxo,
—OCH3,
—C(O)NHCH2CH2OCH2CH3;
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1)

The compound of claim 1 selected from:
3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
(trans)-N-(1-Butyl-1H-tetrazol-5-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(1-methyl-1H-tetrazol-5-yl)cyclobutanecarboxamide;
(trans)-N-(1-(5-Cyanothiazol-2-yl)azetidin-3-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
Methyl 2-(3-((trans)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamido)azetidin-1-yl)thiazole-5-carbimidate;
2-(3-((trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamido)azetidin-1-yl)thiazole-5-carboxamide;
2-(3-((trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamido)azetidin-1-yl)pyrimidine-4-carboxamide;
(trans)-N-(1-(4-Cyanopyrimidin-2-yl)azetidin-3-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-N-(1-(2-Chloropyrimidin-4-yl)azetidin-3-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-N-(1-(4-Chloropyrimidin-2-yl)azetidin-3-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(1-(5-fluoropyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Cyclopropyl-2-hydroxyethoxy)cyclohexyl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(pyrimidin-2-ylamino)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Cyclopropyl-2-hydroxpropoxy)cyclohexyl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(5-(hydroxymethyl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-(2-((trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamido)thiazol-4-yl)methyl3-(2-(difluoromethoxy)-5- fluorophenoxy)cyclobutanecarboxylate;
(trans)-(2-Aminothiazol-4-yl)methyl3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxylate;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(4-(hydroxymethyl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-(1-(2,2-Difluoroethyl)azetidin-3-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-N-(5-(tert-Butyl)-1,3,4-oxadiazol-2-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(1-(pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(1-(pyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(3,3-Difluoroazetidin-1-yl)cyclohexyl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(((S)-1,1,1-trifluoro-3-hydroxpropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(1-(1,1-difluoropropan-2-yl)piperidin-4-yl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(pyrimidin-5-yl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-((1,1-difluoropropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(2-oxoindolin-1-l)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(trans)-4-(1-hydroxyethyl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(Cyclopropyl(hydroxy)methyl)cyclohexyl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(1,1,1-trifluoro-2-hydroxpropan-2-Acyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-hydroxy-4-methylcyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-3-hydroxy-3-methylcyclobutyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((cis)-3-hydroxy-3-methylcyclobutyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(3-hydroxy-3-methylcyclobutyl)cyclobutanecarboxamide;
Ethyl 2-((trans)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamido)thiazole-4-carboxylate;
(trans)-N-(4-(Cyclopropanecarbonyl)thiazol-2-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(2-hydroxy-2-methylpropoxy)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxamide;
6-(3-((trans)-3-(Benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)nicotinamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-cyanopyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
6-(3-((trans)-3-(Benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)-N-methylnicotinamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-methylpyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-((1,1-difluoropropan-2-yl)amino)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-fluoropyrimidin-2-yl)piperidin-4-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-7-yloxy)-N-(1-(5-fluoropyrimidin-2-yl)piperidin-4-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-7-yloxy)-N-(1-(5-fluoropyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-fluoropyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
Methyl 2-(3-((trans)-3-(benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)oxazole-4-carboxylate;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-((1,1-difluoropropan-2-y1)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(1-(4-Acetyloxazol-2-yl)azetidin-3-yl)-3-(benzo[d]thiazol-4-yloxy)cyclobutanecarboxamide;
Ethyl 2-(3-((trans)-3-(benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)oxazole-5-carboxylate;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-(2-hydroxpropan-2-yl)oxazol-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-methylpyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-6-(2-hydroxpropan-2-yl)tetrahydro-2H-pyran-3-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(4-cyanopyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(((S)-1,1,1-trifluoro-3-hydroxpropan-2-yl)amino)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(4-(2-hydroxpropan-2-yl)thiazol-2-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-(2-hydroxpropan-2-yl)thiazol-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(3,3-difluoroazetidin-1-yl)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-methoxyethoxy)cyclohexyl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-methoxyethoxy)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-chloropyrimidin-4-yl)azetidin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-fluoropyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
N-(4-Acetylthiazol-2-yl)-3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(pyridin-4-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-cyclohexylazetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1((E)-N′-cyano-N-methylcarbamimidoyl)azetidin-3-yl)cyclobutanecarboxamide;
tert-Butyl((trans)-3-((trans)-3-(benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)cyclobutyl)carbamate;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-3-(3-cyclohexylureido)cyclobutyl)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(benzo[d]thiazol-4-yloxy)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-chloropyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-(isopropylamino)pyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-cyanothiazol-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
2-(3-((trans)-3-(Benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)thiazole-5-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-((2-methoxyethyl)amino)pyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-3-(pyrimidin-2-ylamino)cyclobutyl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(4-chloropyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(4-(dimethylamino)pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2-(dimethylamino)pyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
2-(3-((trans)-3-(Benzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)pyrimidine-4-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(4-cyanopyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-fluoropyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(5-methyl-1,3,4-oxadiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridin-2-yl)pyrrolidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(6-(2-hydroxpropan-2-yl)spiro[3.3]heptan-2-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(1,1,1-trifluoropropan-2-yl)piperidin-4-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridin-2-yl)pyrrolidin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridin-2-yl)piperidin-4-yl)azetidine-1-carboxamide;
Benzyl 4-(3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamido)piperidine-1-carboxylate;
3-(Benzo[d]thiazol-4-yloxy)-N-(tetrahydro-2H-pyran-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-1-carboxamide;
N-(1-Acetylpiperidin-3-yl)-3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamide;
Methyl 3-(3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamido)piperidine-1-carboxylate;
Methyl 2-((3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamido)methyl)morpholine-4-carboxylate;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)azetidine-1-carbothioamide;
tert-Butyl 4-(3-(benzo[d]thiazol-4-yloxy)azetidine-1carboxamido)piperidine-1-carboxylate;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(methylsulfonyl)piperidin-4-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-(methylsulfonyl)cyclohexyl)azetidine-1-carboxamide;
(S)-3-(Benzo[d]thiazol-4-yloxy)-N-(2-oxopyrrolidin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-cyclopropyl-2-hydroxpropoxy)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(1,1-dioxidoisothiazolidin-2-yl)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(3-methyl-2-oxoimidazolidin-1-yl)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-oxooxazolidin-3-yl)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-6-(2-hydroxpropan-2-yl)tetrahydro-2H-pyran-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-hydroxy-4-methylcyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxy-2-methylpropoxy)cyclohexyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
6-(3-((trans)-3-(6-Fluorobenzo[d]thiazol-4-yloxy)cyclobutanecarboxamido)azetidin-1-yl)nicotinamide;
2-(3-((trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)cyclobutanecarboxamido)azetidin-1-yl)-5-methylpyridine 1-oxide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-methylpyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-(hydroxymethyl)pyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-(hydroxymethyl)pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-4-(2-methoxyethoxy)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(6-(2-hydroxypropan-2-yl)spiro[3.3]heptan-2-Acyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-fluoropyrimidin-2-yl)piperidin-4-yl)cyclobutanecarboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(5-fluoropyrimidin-2-yl)piperidin-4-yl)azetidine-1-carboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(5-fluoropyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-fluoropyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-((1,1-Difluoropropan-2-yl)amino)cyclohexyl)-3-((6-fluorobenzo[d]thiazol-4-yl)oxy)cyclobutanecarboxamide;
3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(2-methylpyrimidin-4-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(2-methylpyrimidin-4-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-((cis)-4-((1,1,1-trifluoro-3-hydroxypropan-2-yl)amino)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((cis)-4-((1,1,1-trifluoro-3-hydroxpropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-4-((1,1,1-trifluoro-3-hydroxpropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-((trans)-6-(2-hydroxypropan-2-yl)tetrahydro-2H-pyran-3-yl)azetidine-1-carboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-((trans)-4-(2-methoxyethoxy)cyclohexyl)azetidine-1-carboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(pyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
N-(1-(2-Chloropyrimidin-4-yl)azetidin-3-yl)-3-((5-fluorobenzo[d]thiazol-7-yl)oxy)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((cis)-3-hydroxy-3-methylcyclobutyl)cyclobutanecarboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(pyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
N-(1-(4-Cyanopyridin-2-yl)azetidin-3-yl)-3-((5-fluorobenzo[d]thiazol-7-yl)oxy)azetidine-1-carboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(5-fluoropyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-fluoropyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(pyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(4-cyclopropylthiazol-2-yl)cyclobutanecarboxamide;
(trans)-34(6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-6-(2-hydroxpropan-2-yl)tetrahydro-2H-pyran-3-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
N-((trans)-4((1,1-Difluoropropan-2-yl)amino)cyclohexyl)-3-((6-fluorobenzo[d]thiazol-4-yl)oxy)azetidine-1-carboxamide;
tert-Butyl 3-((trans)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamido)pyrrolidine-1-carboxylate;
(trans)-N-(1-(5-Cyanothiazol-2-yl)pyrrolidin-3-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-N-(1-(4-Cyanopyridin-2-yl)pyrrolidin-3-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(indolin-1-yl)cyclobutanecarboxamide;
(trans)-N-(1-(5-Cyanothiazol-2-yl)azetidin-3-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-N-(2-(4-Cyanopyridin-2-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-N-(1-(4-Cyanopyridin-2-yl)azetidin-3-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-((trans)-4-methoxycyclohexyl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-((trans)-4-(3-oxomorpholino)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(1-(1-methyl-1 H-tetrazol-5-yl)piperidin-4-yl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(1-(thiazol-2-yl)piperidin-4-yl)cyclobutanecarboxamide;
(trans)-N-(1-(4-Cyanopyridin-2-yl)piperidin-4-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-N-(1-(3-Chloro-4-methoxybenzyl)piperidin-4-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(1-(pyridin-2-yl)piperidin-4-yl)cyclobutanecarboxamide;
2-((trans)-3-(5-Fluoro-2-methoxyphenoxy)cyclobutanecarboxamido)-N,N-dimethyloxazole-4-carboxamide;
(trans)-N-(6-Cyanopyridin-2-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(6-(2-hydroxpropan-2-yl)spiro[3.3]heptan-2-yl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-((trans)-4-((1,1,1-trifluoropropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-3-(5-Fluoro-2-methoxyphenoxy)cyclobutyl)-4-(2-hydroxpropan-2-yl)cyclohexanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-N-(5-Acetylthiazol-2-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-(5-methyl-1,3,4-thiadiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-(4-Cyclopropylthiazol-2-yl)-3-(5-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(5-Fluoro-2-methoxyphenoxy)-N-((trans)-4-(2-hydroxy-2-methylpropoxy)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(6-(2-Hydroxypropan-2-yl)spiro[3.3]heptan-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
Ethyl 2-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)oxazole-4-carboxylate;
N,N-Dimethyl-2-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)oxazole-4-carboxamide;
(trans)-3-(Quinolin-8-yloxy)-N-((trans)-4-((1,1,1-trifluoropropan-2-yl)amino)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(5-Acetyloxazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4,5-Dimethyloxazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
Ethyl 5-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)-4H-1,2,4-triazole-3-carboxylate;
(trans)-N-(5-Methyloxazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-Cyclopropyloxazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-(tert-Butyl)-1,3,4-oxadiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-((trans)-4-((1,1-Difluoropropan-2-yl)amino)cyclohexyl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(6-Methylpyridin-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-((trans)-4-Hydroxy-4-methylcyclohexyl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(Pyridin-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
trans-3-(8-Quinolinyloxy)-N-1,3-thiazol-2-ylcyclobutanecarboxamide;
N-((trans)-4-(2-Hydroxpropan-2-yl)cyclohexyl)-3-(quinolin-8-yloxy)azetidine-1-carboxamide;
trans-N-(4-Acetylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-(Quinolin-8-yloxy)-N-(4-(1,1,1-trifluoro-2-hydroxpropan-2-yl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-(4-Cyanothiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide, trifluoroacetic acid salt;
2-((trans)-3-(Quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-4-carboxamide, trifluoroacetic acid salt;
(trans)-N-(5-Cyanothiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
2-((trans)-3-(Quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-5-carboxamide;
Ethyl 2-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-4-carboxylate;
2-((trans)-3-(Quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-4-carboxylic acid;
(trans)-N-(4-(Cyclopropanecarbonyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-((trans)-6-(2-Hydroxpropan-2-yl)tetrahydro-2H-pyran-3-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
N-Methyl-2-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-4-carboxamide, trifluoroacetic acid salt;
N,N-Dimethyl-2-((trans)-3-(quinolin-8-yloxy)cyclobutanecarboxamido)thiazole-4-carboxamide, trifluoroacetic acid salt;
(trans)-N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-(2-Hydroxypropan-2-yl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-(Quinolin-8-yloxy)-N-(4-(trifluoromethyl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-(5-Acetylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-Methyl-1,3,4-thiadiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-(2-Hydroxpropan-2-yl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-(Prop-1-en-2-yl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-Isopropylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-Cyclopropylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(Oxazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-(2-Hydroxy-2-methylpropyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-(Hydroxymethyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-(tert-Butyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(2,3-Dihydro-1H-inden-1-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(5-(2-Hydroxy-2-methylpropyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(3-Cyclopropyl-1-methyl-1H-pyrazol-5-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-(Hydroxymethyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-(Quinolin-8-yloxy)-N-(1,3,4-thiadiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-(5-Methylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(4-Methylthiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-(1-(Methylsulfonyl)piperidin-4-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Hydroxy-2-methylpropoxy)cyclohexyl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-(Quinolin-8-ylamino)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Hydroxypropan-2-yl)cyclohexyl)-3-(quinolin-8-ylamino)cyclobutanecarboxamide;
(trans)-N-((trans)-3-(2-Hydroxypropan-2-yl)cyclobutyl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-(Quinolin-8-yloxy)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)cyclobutanecarboxamide;
N-((trans)-4-(2-Hydroxypropan-2-yl)cyclohexyl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide;
N-((trans)-4-(2-Hydroxypropan-2-yl)cyclohexyl)-3-(thieno[3,2-b]pyridin-3-yloxy)azetidine-1-carboxamide;
(trans)-3-((5-Fluorobenzofuran-7-yl)oxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(3-Bromophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2,5-Difluorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-Chloro-5-fluorophenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(5-methylpyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-((5-Fluorobenzo[d]thiazol-7-yl)oxy)-N-(1-(5-methylpyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(6-propionylspiro[3.3]heptan-2-yl)cyclobutanecarboxamide;
N-(2-Ethoxyethyl)-6-(3-((trans)-3-((6-fluorobenzo[d]thiazol-4-yl)oxy)cyclobutanecarboxamido)azetidin-1-yl)pyridazine-3-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(pyrazin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-methylazetidine-1-carboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(3-methyl-1-(pyridazin-3-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(3-methyl-1-(pyrimidin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-methylpyridin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)-2-methylazetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-methylpyridazin-3-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(4-(methylsulfonyl)phenyl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(4-morpholinophenyl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-(5-methylpyridin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyridazin-3-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-(pyrazin-2-yl)azetidin-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(2-fluoro-4-(methylsulfonyl)phenyl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(3-morpholinophenyl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1-methyl-1H-pyrazol-5-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(thiophen-2-ylmethyl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-methyl-1-(pyrimidin-2-yl)azetidin-3-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(thiophen-3-ylmethyl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-cyclohexylcyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-((5-methylfuran-2-yl)methyl)cyclobutanecarboxamide;
3-(Fluoro(quinolin-8-yl)methyl)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-(2;5-Dichlorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
N-((trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-3-(2-(trifluoromethoxy)phenoxy)azetidine-1-carboxamide;
(trans)-N-((trans)-4-(2-Hydroxypropan-2-yl)cyclohexyl)-3-(2-(trifluoromethoxy)phenoxy)cyclobutanecarboxamide;
3-(Benzofuran-7-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
(trans)-3-(Benzofuran-7-yloxy)-N-(5-cyanothiazol-2-yl)cyclobutanecarboxamide;
Ethyl 2-(2-((trans)-3-(benzofuran-7-yloxy)cyclobutanecarboxamido)thiazol-4-yl)acetate;
Ethyl 2-(5-((trans)-3-(benzofuran-7-yloxy)cyclobutanecarboxamido)-1,3,4-thiadiazol-2-yl)acetate;
(trans)-N-(5-Acetylthiazol-2-yl)-3-(benzofuran-7-yloxy)cyclobutanecarboxamide;
(trans)-3-(Benzofuran-7-yloxy)-N-(5-(2-hydroxypropan-2-yl)thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(Benzofuran-7-yloxy)-N-(5-methyl-1,3,4-thiadiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(Benzofuran-7-yloxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((2;3-Dihydrobenzofuran-7-yl)oxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((3-Bromobenzofuran-7-yl)oxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Hydroxpropan-2-yl)cyclohexyl)-3-((3-methylbenzofuran-7-yl)oxy)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-((3-bromobenzofuran-7-yl)oxy)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(5-chloro-2-(difluoromethoxy)phenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Chloro-2-(difluoromethoxy) phenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(5-chloro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(5-Chloro-2-methoxyphenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(4-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(4-Fluoro-2-methoxyphenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(2-(Difluoromethoxy)phenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-(4-Acetylthiazol-2-yl)-3-(4-fluoro-2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-((3-Fluoroquinolin-8-yl)oxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((3-Fluoroquinolin-8-yl)oxy)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(2-Chlorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(3,5-Difluorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-3-(2-methoxyphenoxy)cyclobutanecarboxamide;
(trans)-3-(3-Ethylphenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(3-Chlorophenoxy)-N-(2,3-dihydro-1H-inden-1-yl)cyclobutanecarboxamide;
(trans)-3-(3-Chlorophenoxy)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-(3-Chlorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(3-Fluorophenoxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-(3-Chloro-5-fluorophenoxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((5-Fluoroquinolin-8-yl)oxy)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-((5-Fluoroquinolin-8-yl)oxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-3-((6-Fluoroquinolin-8-yl)oxy)-N-((trans)-3-(2-hydroxpropan-2-yl)cyclobutyl)cyclobutanecarboxamide;
(trans)-3-((6-Fluoroquinolin-8-yl)oxy)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluoroquinolin-8-yl)oxy)-N-((trans)-4-(2-hydroxpropan-2-yl)cyclohexyl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Hydroxpropan-2-yl)cyclohexyl)-3-(quinazolin-8-yloxy)cyclobutanecarboxamide;
(trans)-3-((1H-Benzo[d]imidazol-4-yl)oxy)-N-(thiazol-2-yl)cyclobutanecarboxamide;
(trans)-N-((trans)-4-(2-Hydroxpropan-2-yl)cyclohexyl)-3-(imidazo[1,2-a]pyridin-8-yloxy)cyclobutanecarboxamide;
3-(Benzo[d]isothiazol-4-yloxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)azetidine-1-carboxamide;
N-((trans)-4-(2-Hydroxpropan-2-Acyclohexyl)-3-((2-methylbenzo[d]thiazol-4-yl)oxy)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(1H-pyrazol-5-yl)cyclobutanecarboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(3-cyclopropyl-1H-pyrazol-5-yl)cyclobutanecarboxamide;
(trans)-3-((6-Fluorobenzo[d]thiazol-4-yl)oxy)-N-(1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl)cyclobutanecarboxamide;
(2S,3S)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-methylazetidine-1-carboxamide;
(2R,3R)-3-(Benzo[d]thiazol-4-yloxy)-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-methylazetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-(methylsulfonyl)phenyl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(6-methylpyrimidin-4-yl)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(2-fluoro-4-(methylsulfonyl)phenyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-morpholinophenyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-morpholinophenyl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-(methylsulfonyl)pyridin-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(2-cyclopropylpyrimidin-4-yl)azetidine-1-carboxamide;
N-(2-Cyclopropylpyrimidin-4-yl)-3-((6-fluorobenzo[d]thiazol-4-yl)oxy)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(3-(pyrimidin-2-ylamino)bicyclo[1.1.1]pentan-1-yl)cyclobutane-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-(2-hydroxpropan-2-yl)bicyclo[1.1.1]pentan-1-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-(2-hydroxypropan-2-yl)cuban-1-yl)azetidine-1-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(3-(2-hydroxpropan-2-yl)bicyclo[1.1.1]pentan-1-yl)cyclobutane-1-carboxamide;
Ethyl (3-((trans)-3-(benzo[d]thiazol-4-yloxy)cyclobutane-1-carboxamido)bicyclo[1. 1. 1]pentan-1-yl)carbamate;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(4-(2-hydroxpropan-2-yl)cuban-1-yl)cyclobutane-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-methyl-1,3,4-thiadiazol-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-methyl-1H-pyrazol-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-methoxypyridin-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-methyl-1H-pyrazol-4-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(1-ethyl-1H-tetrazol-5-yl)azetidine-1-carboxamide;
Methyl 4-((trans)-3-(benzo[d]thiazol-4-yloxy)cyclobutane-1-carboxamido)bicyclo[2.2.2]octane-1-carboxylate;
Methyl 4-(3-(benzo[d]thiazol-4-yloxy)azetidine-1-carboxamido)bicyclo[2.2.2]octane-1-carboxylate;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-isopropyl-1,3,4-oxadiazol-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(4-cyano-3-methyl-1H-pyrazol-5-yl)azetidine-1-carboxamide;
4-((1-(((trans)-4-(2-Hydroxpropan-2-yl)cyclohexyl)carbamoyl)azetidin-3-yl)oxy)benzo[d]thiazole-6-carboxamide;
(trans)-3-(Benzo[d]thiazol-4-yloxy)-N-(5-methyl-1,3,4-thiadiazol-2-yl)cyclobutane-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-(tert-butyl)-1,3,4-thiadiazol-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)azetidine-1-carboxamide;
(trans)-N-(5-(Ethoxymethyl)-1H-1,2,4-triazol-3-yl)-3-((6-fluorobenzo[d]thiazol-4-yl)oxy)cyclobutanecarboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(5-methyl-1,2,4-thiadiazol-3-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-isopropyl-1,2,4-thiadiazol-5-yl)azetidine-1-carboxamide;
3-(Benzo[d]thiazol-4-yloxy)-N-(3-cyclopropyl-1,2,4-thiadiazol-5-yl)azetidine-1-carboxamide; and
3-(Benzo[d]thiazol-4-yloxy)-N-(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)azetidine-1-carboxamide;
or a pharmaceutically acceptable salt thereof.

### Claim 6

(canceled)

### Claim 7

(canceled)

### Claim 8

(canceled)

### Claim 9

(canceled)

### Claim 10 (depends on 1)

A method for the treatment of disorders in which inhibition of H-PGDS is beneficial in a human comprising administering to the human in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1.

### Claim 11 (depends on 1)

A method for the treatment of allergic diseases and other inflammatory conditions such as asthma, aspirin-exacerbated respiratory disease (AERD), cough, chronic obstructive pulmonary disease (including chronic bronchitis and emphysema), bronchoconstriction, allergic rhinitis (seasonal or perennial), vasomotor rhinitis, rhinoconjuctivitis, allergic conjunctivitis, food allergy, hypersensitivity lung diseases, eosinophilic syndromes including eosinophilic asthma, eosinophilic pneumonitis, eosinophilic oesophagitis, eosinophilic granuloma, delayed-type hypersensitivity disorders, atherosclerosis, rheumatoid arthritis, pancreatitis, gastritis, inflammatory bowel disease, osteoarthritis, psoriasis, sarcoidosis, pulmonary fibrosis, respiratory distress syndrome, bronchiolitis, sinusitis, cystic fibrosis, actinic keratosis, skin dysplasia, chronic urticaria, eczema and all types of dermatitis including atopic dermatitis or contact dermatitis in a human comprising administering to the human in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1.

### Claim 12 (depends on 1)

A method for the treatment of asthma in a human comprising administering to the human in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1.

### Claim 13 (depends on 1)

A method for the treatment of Duchenne Muscular Dystrophy in a human comprising administering to the human in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1.

### Claim 14 (depends on 1)

A pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1 and one or more pharmaceutically acceptable carriers or excipients.

### Claim 15 (depends on 14)

A pharmaceutical composition as claimed in claim 14 for the treatment of a disorder in which inhibition of H-PGDS is beneficial.

### Claim 16 (depends on 15)

A pharmaceutical composition as claimed in claim 15 for the treatment or prophylaxis of asthma.

### Claim 17 (depends on 15)

A pharmaceutical composition as claimed in claim 15 for the treatment or prophylaxis of Duchenne Muscular Dystrophy.

### Claim 18 (depends on 1)

A method for the treatment of neuromuscular-related conditions selected from: Duchenne muscular dystrophy (MD), Becker MD, Congenital MD (Fukuyama), Dreifuss MD, Limb girdle MD, Fascioscapulohumeral MD, Myotonic dystrophy type I (DM1 or Steinert's), myotonic dystrophy type II (DM2 or proximal myotonic myopathy), congenital myotonia, polymyositis, dermatomyositis, amyotrophic Lateral Sclerosis (ALS), muscle injury, surgery-related muscle injury, traumatic muscle injury, work-related skeletal muscle injury, overtraining-related muscle injury, muscle damage due to knee replacement, muscle damage due to anterior cruciate ligament (ACL) repair, muscle damage due to plastic surgery, muscle damage due to hip replacement surgery, muscle damage due to joint replacement surgery, muscle damage due to tendon repair surgery, muscle damage due to surgical repair of rotator cuff disease, muscle damage due to surgical repair of rotator cuff injury, muscle damage due to amputation, battlefield muscle injuries, auto accident-related muscle injuries, sports-related muscle injuries, muscle lacerations, traumatic injury due to blunt force contusions, traumatic injury due to shrapnel wounds, muscle pulls or tears, traumatic injury due to burns, acute muscle strains, chronic muscle strains, weight or force stress muscle injuries, repetitive stress muscle injuries, avulsion muscle injury, compartment syndrome, muscle injuries caused by highly repetitive motions, muscle injuries caused by forceful motions, muscle injuries caused by awkward postures, muscle injuries caused by prolonged and forceful mechanical coupling between the body and an object, muscle injuries caused by vibration, muscle injuries due to unrepaired or under-repaired muscle damage coincident with a lack of recovery or lack of an increase of physical work capacity, exercise-induced delayed onset muscle soreness (DOMS), wound healing and disuse atrophy in a human comprising administering to the human in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof according to claim 1.

### Claim 19 (depends on 14)

A pharmaceutical composition as claimed in claim 14 for the treatment of neuromuscular-related conditions selected from: Duchenne muscular dystrophy (MD), Becker MD, Congenital MD (Fukuyama), Dreifuss MD, Limb girdle MD, Fascioscapulohumeral MD, Myotonic dystrophy type I (DM1 or Steinert's), myotonic dystrophy type II (DM2 or proximal myotonic myopathy), congenital myotonia, polymyositis, dermatomyositis, amyotrophic Lateral Sclerosis (ALS), muscle injury, surgery-related muscle injury, traumatic muscle injury, work-related skeletal muscle injury, overtraining-related muscle injury, muscle damage due to knee replacement, muscle damage due to anterior cruciate ligament (ACL) repair, muscle damage due to plastic surgery, muscle damage due to hip replacement surgery, muscle damage due to joint replacement surgery, muscle damage due to tendon repair surgery, muscle damage due to surgical repair of rotator cuff disease, muscle damage due to surgical repair of rotator cuff injury, muscle damage due to amputation, battlefield muscle injuries, auto accident-related muscle injuries, sports-related muscle injuries, muscle lacerations, traumatic injury due to blunt force contusions, traumatic injury due to shrapnel wounds, muscle pulls or tears, traumatic injury due to burns, acute muscle strains, chronic muscle strains, weight or force stress muscle injuries, repetitive stress muscle injuries, avulsion muscle injury, compartment syndrome, muscle injuries caused by highly repetitive motions, muscle injuries caused by forceful motions, muscle injuries caused by awkward postures, muscle injuries caused by prolonged and forceful mechanical coupling between the body and an object, muscle injuries caused by vibration, muscle injuries due to unrepaired or under-repaired muscle damage coincident with a lack of recovery or lack of an increase of physical work capacity, exercise-induced delayed onset muscle soreness (DOMS), wound healing and disuse atrophy.

### Claim 20 (depends on 1)

A pharmaceutical composition comprising from 0.5 to 1,000 mg of a compound or pharmaceutically acceptable salt thereof as defined in claim 1, and from 0.5 to 1,000 mg of a pharmaceutically acceptable excipient.

### Claim 21

(canceled)